Chemical immobilization of antimicrobial peptides on biomaterial surfaces.
Chemical immobilization of antimicrobial peptides on biomaterial surfaces.
复制标题
抗菌肽在生物材料表面的化学固定化。
DOI:
10.2741/s453
复制
发表时间:
2016
期刊:
影响因子:
--
通讯作者:
C. Andrade
中科院分区:
文献类型:
--
作者:
Rafael R. Silva;K. Y. Avelino;K. L. Ribeiro;O. Franco;Maria D. L. Oliveira;C. Andrade
The hospital infections associated with surgical procedures and implants still represents a severe problem to modern society. Therefore, new strategies to combat bacterial infections mainly caused by microorganisms resistant to conventional antibiotics are extremely necessary. In this context, antimicrobial peptides have gained prominence due their biocompatibility, low toxicity and effectiveness. The immobilization of antimicrobial peptides (AMPs) onto a biomaterial surface is an excellent alternative to the development of new biodevices with microbicide properties. Herein, we describe reports related to physical-chemical characterization, in vitro/in vivo studies and clinical applicability. In this review, we focused on the AMPs mechanisms of action, different peptide immobilization strategies on solid surface and their microbicide effectiveness.
影响因子:
2.9
作者:
SEHGAL, D;VIJAY, IK
通讯作者:
VIJAY, IK
影响因子:
2.9
作者:
STAROS, JV;WRIGHT, RW;SWINGLE, DM
通讯作者:
SWINGLE, DM
影响因子:
3.6
作者:
Bencharit S;Byrd WC;Altarawneh S;Hosseini B;Leong A;Reside G;Morelli T;Offenbacher S
通讯作者:
Offenbacher S