Chemical immobilization of antimicrobial peptides on biomaterial surfaces.

Chemical immobilization of antimicrobial peptides on biomaterial surfaces.
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抗菌肽在生物材料表面的化学固定化。

DOI:
10.2741/s453
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发表时间:
2016
期刊:
Frontiers in bioscience
影响因子:
--
通讯作者:
C. Andrade
C. Andrade
中科院分区:
--
文献类型:
--
作者:
Rafael R. Silva;K. Y. Avelino;K. L. Ribeiro;O. Franco;Maria D. L. Oliveira;C. Andrade

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与外科手术和植入物相关的医院感染仍然是现代社会的一个严重问题。因此,对抗主要由对常规抗生素耐药的微生物引起的细菌感染的新策略是极其必要的。在这种情况下,抗微生物肽由于其生物相容性、低毒性和有效性而获得突出。将抗菌肽固定到生物材料表面是开发具有杀微生物特性的新型生物装置的一个很好的选择。在此,我们描述了与理化表征、体外/体内研究和临床适用性相关的报告。本文就抗菌肽的作用机制、固定化方法及其杀菌效果进行了综述。
The hospital infections associated with surgical procedures and implants still represents a severe problem to modern society. Therefore, new strategies to combat bacterial infections mainly caused by microorganisms resistant to conventional antibiotics are extremely necessary. In this context, antimicrobial peptides have gained prominence due their biocompatibility, low toxicity and effectiveness. The immobilization of antimicrobial peptides (AMPs) onto a biomaterial surface is an excellent alternative to the development of new biodevices with microbicide properties. Herein, we describe reports related to physical-chemical characterization, in vitro/in vivo studies and clinical applicability. In this review, we focused on the AMPs mechanisms of action, different peptide immobilization strategies on solid surface and their microbicide effectiveness.
DOI: 10.1006/abio.1994.1144
发表时间: 1994-04-01
影响因子: 2.9
作者:
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通讯作者: VIJAY, IK
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