Urinary phthalate metabolites in relation to preterm birth in Mexico city.
Urinary phthalate metabolites in relation to preterm birth in Mexico city.
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DOI：
10.1289/ehp.0800522
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发表时间：
2009-10
影响因子：
10.4
通讯作者：
Téllez-Rojo MM
中科院分区：
文献类型：
--
作者：
Meeker JD;Hu H;Cantonwine DE;Lamadrid-Figueroa H;Calafat AM;Ettinger AS;Hernandez-Avila M;Loch-Caruso R;Téllez-Rojo MM
在过去的几十年里，早产率一直在上升。导致这一趋势的因素在很大程度上仍不清楚，暴露在环境污染物中可能起到一定作用。我们调查了邻苯二甲酸盐暴露与早产的关系。在一项大型的墨西哥出生队列研究中，我们比较了30名早产妇女(妊娠37周)和30名对照组(≥，妊娠37周)的晚期尿邻苯二甲酸酯代谢物浓度。大多数代谢物的浓度与美国女性的报告相似，尽管在本研究中邻苯二甲酸单丁酯(MBP)的浓度较高，邻苯二甲酸单苄酯(MBZP)的浓度较低。在校正尿液稀释度之前的粗略比较中，在随后早产的妇女中，邻苯二甲酸酯代谢物MBP、MBzP、邻苯二甲酸单(3-羧丙基)酯和邻苯二甲酸二(2-乙基己基)酯的四种代谢物的几何平均尿液浓度更高。这些差异仍然存在，但经过比重或肌酐校正后有所缩小。在调整了潜在混杂因素的多变量Logistic回归分析中，发现邻苯二甲酸酯代谢物浓度高于中值水平的几率较高。我们发现，在墨西哥，邻苯二甲酸盐暴露在这群孕妇中很普遍，一些邻苯二甲酸盐可能与早产有关。
Rates of preterm birth have been rising over the past several decades. Factors contributing to this trend remain largely unclear, and exposure to environmental contaminants may play a role. We investigated the relationship between phthalate exposure and preterm birth. Within a large Mexican birth cohort study, we compared third-trimester urinary phthalate metabolite concentrations in 30 women who delivered preterm (< 37 weeks of gestation) with those of 30 controls (≥ 37 weeks of gestation). Concentrations of most of the metabolites were similar to those reported among U.S. females, although in the present study mono-n-butyl phthalate (MBP) concentrations were higher and monobenzyl phthalate (MBzP) concentrations lower. In a crude comparison before correcting for urinary dilution, geometric mean urinary concentrations were higher for the phthalate metabolites MBP, MBzP, mono(3-carboxylpropyl) phthalate, and four metabolites of di(2-ethyl-hexyl) phthalate among women who subsequently delivered preterm. These differences remained, but were somewhat lessened, after correction by specific gravity or creatinine. In multivariate logistic regression analysis adjusted for potential confounders, elevated odds of having phthalate metabolite concentrations above the median level were found. We found that phthalate exposure is prevalent among this group of pregnant women in Mexico and that some phthalates may be associated with preterm birth.
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DOI：
10.1111/j.1471-0528.1981.tb00930.x
发表时间：
1981-01-01
期刊：
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY
影响因子：
--
作者：
DAVISON, JM;NOBLE, MCB
通讯作者：
NOBLE, MCB
影响因子：
2.5
作者：
Kato, K;Silva, MJ;Barr, DB
通讯作者：
Barr, DB
影响因子：
3.5
作者：
ANDREWS, KW;SAVITZ, DA;HERTZPICCIOTTO, I
通讯作者：
HERTZPICCIOTTO, I
影响因子：
4.1
作者：
Kasahara, E;Sato, EF;Inoue, M
通讯作者：
Inoue, M
女性生殖系统中邻苯二甲酸酯毒性的机制。
影响因子：
10.4
作者：
Lovekamp-Swan, T;Davis, BJ
通讯作者：
Davis, BJ