Oral Cnm-positive Streptococcus Mutans Expressing Collagen Binding Activity is a Risk Factor for Cerebral Microbleeds and Cognitive Impairment.
Oral Cnm-positive Streptococcus Mutans Expressing Collagen Binding Activity is a Risk Factor for Cerebral Microbleeds and Cognitive Impairment.
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DOI：
10.1038/srep38561
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发表时间：
2016-12-09
影响因子：
4.6
通讯作者：
Watanabe Y
中科院分区：
文献类型：
--
作者：
Watanabe I;Kuriyama N;Miyatani F;Nomura R;Naka S;Nakano K;Ihara M;Iwai K;Matsui D;Ozaki E;Koyama T;Nishigaki M;Yamamoto T;Tamura A;Mizuno T;Akazawa K;Takada A;Takeda K;Yamada K;Nakagawa M;Tanaka T;Kanamura N;Friedland RP;Watanabe Y
脑微出血（CMB）是中风和痴呆的重要危险因素。我们已经表明，胶原结合表面Cnm蛋白表达的cnm阳性变形链球菌参与的CMB的发展。然而，cnm阳性S。变形链球菌是否与CMB的性质或认知障碍有关尚不清楚。对279名社区居民（70.0岁）进行了cnm阳性S。通过PCR检测唾液中的变异体，并评估胶原蛋白结合活性、CMBs和认知功能。Cnm阳性S.变形链球菌在CMB患者中的检出率高于非CMB患者（p < 0.01）。在S组中，发生CML的风险显着更高（比值比= 14.3）。表达胶原结合活性的变异体，与没有发现的组相比。cnm阳性的受试者中，深部CMB更常见（67%），认知功能较低。表达胶原结合活性的变异蛋白。这项工作支持口腔健康在中风和痴呆症中的作用，并提出了相互作用的分子机制。
Cerebral microbleeds (CMBs) are an important risk factor for stroke and dementia. We have shown that the collagen binding surface Cnm protein expressed on cnm-positive Streptococcus mutans is involved in the development of CMBs. However, whether the collagen binding activity of cnm-positive S. mutans is related to the nature of the CMBs or to cognitive impairment is unclear. Two-hundred seventy nine community residents (70.0 years) were examined for the presence or absence of cnm-positive S. mutans in the saliva by PCR and collagen binding activity, CMBs, and cognitive function were evaluated. Cnm-positive S. mutans was detected more often among subjects with CMBs (p < 0.01) than those without. The risk of CMBs was significantly higher (odds ratio = 14.3) in the group with S. mutans expressing collagen binding activity, as compared to the group without that finding. Deep CMBs were more frequent (67%) and cognitive function was lower among subjects with cnm-positive S. mutans expressing collagen binding activity. This work supports the role of oral health in stroke and dementia and proposes a molecular mechanism for the interaction.
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