Microstructural abnormalities in subcortical reward circuitry of subjects with major depressive disorder.
Microstructural abnormalities in subcortical reward circuitry of subjects with major depressive disorder.
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DOI：
10.1371/journal.pone.0013945
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发表时间：
2010-11-29
期刊：
影响因子：
3.7
通讯作者：
Phenotype Genotype Project on Addiction and Mood Disorders
中科院分区：
文献类型：
--
作者：
Blood AJ;Iosifescu DV;Makris N;Perlis RH;Kennedy DN;Dougherty DD;Kim BW;Lee MJ;Wu S;Lee S;Calhoun J;Hodge SM;Fava M;Rosen BR;Smoller JW;Gasic GP;Breiter HC;Phenotype Genotype Project on Addiction and Mood Disorders
以往对抑郁症的研究主要集中在前额叶皮层和颞叶内侧区的异常。中脑和皮层下区域如腹侧被盖区/黑质（VTA/SN）和内侧前脑束（MFB）对MDD的研究很少。我们调查了微结构的完整性，这一电路使用扩散张量成像（DTI）在22 MDD的主题，并将其与22名匹配的健康对照组。在MDD受试者中，右侧VT的各向异性分数（FA）值增加，背外侧前额叶白色物质的FA值减少。随访分析表明，两个不同的亚组的MDD患者，表现出非重叠的异常奖励/厌恶电路。在VT中FA值异常的MDD亚组比VT中FA值正常的亚组表现出显著更大的特质焦虑，但亚组在快感缺乏、悲伤或总体抑郁严重程度方面没有差异。这些研究结果表明，抑郁症可能与大脑奖励/厌恶区域的异常微结构有关，并且可能存在至少两种微结构异常亚型，每种亚型都会影响抑郁症的核心症状。
Previous studies of major depressive disorder (MDD) have focused on abnormalities in the prefrontal cortex and medial temporal regions. There has been little investigation in MDD of midbrain and subcortical regions central to reward/aversion function, such as the ventral tegmental area/substantia nigra (VTA/SN), and medial forebrain bundle (MFB). We investigated the microstructural integrity of this circuitry using diffusion tensor imaging (DTI) in 22 MDD subjects and compared them with 22 matched healthy control subjects. Fractional anisotropy (FA) values were increased in the right VT and reduced in dorsolateral prefrontal white matter in MDD subjects. Follow-up analysis suggested two distinct subgroups of MDD patients, which exhibited non-overlapping abnormalities in reward/aversion circuitry. The MDD subgroup with abnormal FA values in VT exhibited significantly greater trait anxiety than the subgroup with normal FA values in VT, but the subgroups did not differ in levels of anhedonia, sadness, or overall depression severity. These findings suggest that MDD may be associated with abnormal microstructure in brain reward/aversion regions, and that there may be at least two subtypes of microstructural abnormalities which each impact core symptoms of depression.
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影响因子：
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