Cortico-amygdalar connectivity and externalizing/internalizing behavior in children with neurodevelopmental disorders.
Cortico-amygdalar connectivity and externalizing/internalizing behavior in children with neurodevelopmental disorders.
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DOI：
10.1007/s00429-022-02483-0
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发表时间：
2022-07
影响因子：
3.1
通讯作者：
Ameis, Stephanie H.
中科院分区：
文献类型：
--
作者：
Nakua, Hajer;Hawco, Colin;Forde, Natalie J.;Jacobs, Grace R.;Joseph, Michael;Voineskos, Aristotle N.;Wheeler, Anne L.;Lai, Meng-Chuan;Szatmari, Peter;Kelley, Elizabeth;Liu, Xudong;Georgiades, Stelios;Nicolson, Rob;Schachar, Russell;Crosbie, Jennifer;Anagnostou, Evdokia;Lerch, Jason P.;Arnold, Paul D.;Ameis, Stephanie H.
关键词：
外化和内化行为导致神经发育障碍儿童的临床损害。尽管在临床和非临床儿科样本中发现了外化或内化行为与皮质-杏仁核连接之间的关联，但以前的研究尚未研究过不同NDD儿童之间是否存在类似的共享关联。多模态神经影像学和行为数据来自安大略省神经发育障碍（POND）网络。POND参与者年龄6-18岁，主要诊断为自闭症谱系障碍（ASD），注意力缺陷/多动障碍（ADHD）或强迫症（OCD），以及典型发育儿童（TDC），T1加权，静息状态fMRI或扩散加权成像（DWI）和父母报告儿童行为检查表（CBCL）数据可用，进行了分析（总n = 346）。外化或内化行为和皮质杏仁核结构和功能连接指数之间的关联进行了检查，使用线性回归，控制年龄，性别和图像模态特定的协变量。行为诊断的相互作用的影响也进行了检查。CBCL测量的外化或内化行为与任何检查的连接指数之间没有显着的线性关联（或诊断行为相互作用效应）。事后自举分析表明这些无效结果的稳定性和可靠性。目前的研究提供的证据对缺乏一个共享的线性关系之间的内在或外在的行为和皮质-杏仁核的连接性能跨诊断样本的儿童与不同的主要NDD诊断和TDC。不同的方法，包括多维行为数据的结合（例如，基于任务的功能磁共振成像）或聚类方法可能需要澄清复杂的脑行为关系相关的外化/内化行为在异质性临床NDD人群。在线版本包含补充材料，可通过10.1007/s 00429 -022-02483-0获得。
Externalizing and internalizing behaviors contribute to clinical impairment in children with neurodevelopmental disorders (NDDs). Although associations between externalizing or internalizing behaviors and cortico-amygdalar connectivity have been found in clinical and non-clinical pediatric samples, no previous study has examined whether similar shared associations are present across children with different NDDs. Multi-modal neuroimaging and behavioral data from the Province of Ontario Neurodevelopmental Disorders (POND) Network were used. POND participants aged 6–18 years with a primary diagnosis of autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD) or obsessive–compulsive disorder (OCD), as well as typically developing children (TDC) with T1-weighted, resting-state fMRI or diffusion weighted imaging (DWI) and parent-report Child Behavioral Checklist (CBCL) data available, were analyzed (total n = 346). Associations between externalizing or internalizing behavior and cortico-amygdalar structural and functional connectivity indices were examined using linear regressions, controlling for age, gender, and image-modality specific covariates. Behavior-by-diagnosis interaction effects were also examined. No significant linear associations (or diagnosis-by-behavior interaction effects) were found between CBCL-measured externalizing or internalizing behaviors and any of the connectivity indices examined. Post-hoc bootstrapping analyses indicated stability and reliability of these null results. The current study provides evidence towards an absence of a shared linear relationship between internalizing or externalizing behaviors and cortico-amygdalar connectivity properties across a transdiagnostic sample of children with different primary NDD diagnoses and TDC. Different methodological approaches, including incorporation of multi-dimensional behavioral data (e.g., task-based fMRI) or clustering approaches may be needed to clarify complex brain-behavior relationships relevant to externalizing/internalizing behaviors in heterogeneous clinical NDD populations. The online version contains supplementary material available at 10.1007/s00429-022-02483-0.
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DOI：
10.1016/j.nicl.2020.102476
发表时间：
2020
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Choi EJ;Vandewouw MM;Taylor MJ;Arnold PD;Brian J;Crosbie J;Kelley E;Lai MC;Liu X;Schachar RJ;Lerch JP;Anagnostou E
通讯作者：
Anagnostou E
影响因子：
1.3
作者：
Achenbach, T M;Ruffle, T M
通讯作者：
Ruffle, T M
影响因子：
10.6
作者：
Aghajani, Moji;Klapwijk, Eduard T.;Colins, Olivier F.
通讯作者：
Colins, Olivier F.
影响因子：
3.1
作者：
Andre, Quinn R.;Geeraert, Bryce L.;Lebel, Catherine
通讯作者：
Lebel, Catherine
影响因子：
3.3
作者：
Anderson, AW
通讯作者：
Anderson, AW