Hippocampal volumes in adolescents with and without a family history of alcoholism.
Hippocampal volumes in adolescents with and without a family history of alcoholism.
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DOI：
10.3109/00952991003736397
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发表时间：
2010-05
期刊：
影响因子：
--
通讯作者：
Tapert SF
中科院分区：
文献类型：
--
作者：
Hanson KL;Medina KL;Nagel BJ;Spadoni AD;Gorlick A;Tapert SF
海马体可能很容易受到青春期大量饮酒的影响，这是神经持续发育的时期。然而，海马体积的差异可能是由于酗酒家族史（FH）等危险因素造成的。我们在开始饮酒之前检查了有或没有酒精中毒家族史的青少年的海马体积。参与者是人口统计学匹配的酒精中毒阳性（n=15；FHP）和阴性（n=15；FHN）FH 的青少年（12-14 岁）。每组由 10 名男性和 5 名女性组成，之前使用过的药物最少。由可靠的评估者在高分辨率磁共振图像上完成手动海马描记，并在分析中控制颅内容积。 FH 组在记忆或海马体积上没有差异，但组 × 性别交互作用 (p<.05) 表明 FHP 男性比 FHN 男性具有更大的左侧海马。女性表现出更大的左右海马不对称性，而男性则表现出更大的左右海马不对称性。对于所有青少年来说，右侧海马体积越大，延迟视觉记忆就越差（p<.01）。酗酒的危险因素，例如酗酒家族史，可能对男孩和女孩的青少年海马发育有不同的影响。结果表明，FH 并没有考虑到先前发现的酗酒青少年左海马体积减少的情况。研究结果是初步的，但表明未来研究饮酒对青少年大脑的影响应该考虑 FH 的影响，尤其是对男孩的影响。
The hippocampus may be vulnerable to the effects of heavy alcohol use during adolescence, which is a time of continued neurodevelopment. However, differences in hippocampal volume may be due to risk factors such as a family history (FH) of alcoholism. We examined hippocampal volumes in youth with and without a FH of alcoholism prior to the initiation of alcohol use. Participants were demographically matched adolescents (aged 12-14) with positive (n=15; FHP) and negative (n=15; FHN) FH of alcoholism. Each group consisted of 10 males and 5 females with minimal previous substance use. Manual hippocampal tracings were completed on high-resolution magnetic resonance images by reliable raters, and intracranial volumes were controlled in analyses. FH groups did not differ on memory or hippocampal volumes, but group × gender interactions (p<.05) indicated that FHP males had larger left hippocampi than FHN males. Females showed greater left versus right hippocampal asymmetry, while males showed larger right versus left asymmetry. For all adolescents, larger right hippocampal volumes predicted poorer delayed visual memory (p<.01). Alcoholism risk factors, such as family history of alcoholism, may differentially influence adolescent hippocampal development for boys as compared to girls. Results suggest that FH does not account for prior findings of reduced left hippocampal volumes in heavy drinking youth. Findings are preliminary, but suggest that future studies examining the effects of alcohol use on the adolescent brain should consider the influence of FH, especially among boys.
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DOI：
10.15288/jsa.1998.59.427
发表时间：
1998-07-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
Brown, SA;Myers, MG;Vik, PW
通讯作者：
Vik, PW
影响因子：
4.6
作者：
SHER, KJ;WALITZER, KS;BRENT, EE
通讯作者：
BRENT, EE
影响因子：
2.3
作者：
Ozkaragoz, T;Satz, P;Noble, EP
通讯作者：
Noble, EP
影响因子：
120.7
作者：
SCHUCKIT, MA
通讯作者：
SCHUCKIT, MA
DOI：
10.1017/s1355617702870011
发表时间：
2002-11-01
影响因子：
2.6
作者：
Tapert, SF;Granholm, E;Brown, SA
通讯作者：
Brown, SA