The BDNF Val66Met Polymorphism (rs6265) Modulates Inflammation and Neurodegeneration in the Early Phases of Multiple Sclerosis.
The BDNF Val66Met Polymorphism (rs6265) Modulates Inflammation and Neurodegeneration in the Early Phases of Multiple Sclerosis.
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DOI：
10.3390/genes13020332
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发表时间：
2022-02-10
期刊：
影响因子：
3.5
通讯作者：
Stampanoni Bassi M
中科院分区：
文献类型：
--
作者：
Dolcetti E;Bruno A;Azzolini F;Gilio L;Moscatelli A;De Vito F;Pavone L;Iezzi E;Gambardella S;Giardina E;Ferese R;Buttari F;Rizzo FR;Furlan R;Finardi A;Musella A;Mandolesi G;Guadalupi L;Centonze D;Stampanoni Bassi M
多发性硬化症（MS）的临床过程受到炎症和神经退行性过程之间相互作用的严重影响。脑源性神经营养因子（BDNF）Val 66 Met多态性（rs6265）是研究最多的单核苷酸多态性（SNP）之一，影响健康个体和几种神经精神疾病的脑功能和神经退行性过程。然而，这种多态性在MS中的作用仍然存在争议。在218例复发缓解型（RR）-MS患者中，我们在诊断时探讨了Val 66 Met多态性、临床特征和脑脊液（CSF）中大量促炎和抗炎分子水平之间的相关性。此外，还评估了Val 66 Met与结构MRI测量之间的相关性。我们通过主成分分析（PCA）确定了Met的存在与细胞因子组合之间的关联，包括促炎分子MCP-1，IL-8，TNF，Eotaxin和MIP-1b。与临床特征无显著相关性。MRI测量结果分析证明，Val 66 Met患者在诊断时皮质厚度降低。我们首次报道了MS患者诊断时Val 66 Met多态性与中枢炎症之间的相关性。这种多态性在炎症和神经退行性过程中的作用可以解释其对MS过程的复杂影响。
The clinical course of multiple sclerosis (MS) is critically influenced by the interplay between inflammatory and neurodegenerative processes. The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism (rs6265), one of the most studied single-nucleotide polymorphisms (SNPs), influences brain functioning and neurodegenerative processes in healthy individuals and in several neuropsychiatric diseases. However, the role of this polymorphism in MS is still controversial. In 218 relapsing–remitting (RR)-MS patients, we explored, at the time of diagnosis, the associations between the Val66Met polymorphism, clinical characteristics, and the cerebrospinal fluid (CSF) levels of a large set of pro-inflammatory and anti-inflammatory molecules. In addition, associations between Val66Met and structural MRI measures were assessed. We identified an association between the presence of Met and a combination of cytokines, identified by principal component analysis (PCA), including the pro-inflammatory molecules MCP-1, IL-8, TNF, Eotaxin, and MIP-1b. No significant associations emerged with clinical characteristics. Analysis of MRI measures evidenced reduced cortical thickness at the time of diagnosis in patients with Val66Met. We report for the first time an association between the Val66Met polymorphism and central inflammation in MS patients at the time of diagnosis. The role of this polymorphism in both inflammatory and neurodegenerative processes may explain its complex influence on the MS course.
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影响因子：
4.4
作者：
Makar, Tapas K.;Trisler, David;Bever, Christopher T.
通讯作者：
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11.4
作者：
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通讯作者：
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