Quantifying blood flow and wall shear stresses in the outflow tract of chick embryonic hearts.

Quantifying blood flow and wall shear stresses in the outflow tract of chick embryonic hearts.
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量化雏鸡胚胎心脏流出道中的血流和壁剪应力。

DOI:
10.1016/j.compstruc.2011.03.003
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发表时间:
2011-06-01
影响因子:
4.7
通讯作者:
Rugonyi, Sandra
Rugonyi, Sandra
中科院分区:
工程技术2区
文献类型:
--
作者:
Liu, Aiping;Nickerson, Andrew;Troyer, Aaron;Yin, Xin;Cary, Robert;Thornburg, Kent;Wang, Ruikang;Rugonyi, Sandra

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血流对心脏组织施加的壁剪切应力(WSS)调节心脏的生长和发育。为了研究血流动力学条件对心脏形态发生的作用,在这里,我们提出了一种结合成像和有限元建模的方法,以量化早期鸡胚胎(21 天孵化期中的第 3 天)心脏流出道 (OFT) 的体内血流动力学和 WSS。我们在鸡胚心脏 OFT 中发现了独特的血流场和 WSS 的不均匀分布,这对 OFT 的形态发生具有生理意义。
Wall shear stresses (WSS) exerted by blood flow on cardiac tissues modulate growth and development of the heart. To study the role of hemodynamic conditions on cardiac morphogenesis, here, we present a methodology that combines imaging and finite element modeling to quantify the in vivo blood flow dynamics and WSS in the cardiac outflow tract (OFT) of early chicken embryos (day 3 out of 21-day incubation period). We found a distinct blood flow field and heterogeneous distribution of WSS in the chicken embryonic heart OFT, which have physiological implications for OFT morphogenesis.
DOI: 10.1016/s0045-7949(02)00077-9
发表时间: 2002-06-01
影响因子: 4.7
作者:
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通讯作者: Zhang, H
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发表时间: 2010-11-01
影响因子: 3.5
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发表时间: 2009-07-01
影响因子: 3.5
作者:
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通讯作者: Rugonyi, Sandra
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发表时间: 2009-01-01
影响因子: 8.7
作者:
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通讯作者: Rugonyi, Sandra
DOI: 10.1161/01.res.68.1.226
发表时间: 1991-01-01
影响因子: 20.1
作者:
KELLER, BB;HU, N;CLARK, EB
通讯作者: CLARK, EB