Factors affecting time to sputum culture conversion and treatment outcome of patients with multidrug-resistant tuberculosis in China.
Factors affecting time to sputum culture conversion and treatment outcome of patients with multidrug-resistant tuberculosis in China.
复制标题
DOI：
10.1186/s12879-018-3021-0
复制
发表时间：
2018-03-06
影响因子：
3.7
通讯作者：
Zhu L
中科院分区：
文献类型：
--
作者：
Liu Q;Lu P;Martinez L;Yang H;Lu W;Ding X;Zhu L
很少有前瞻性队列研究调查了耐多药结核病（MDR-TB）患者治疗结果与痰培养转化之间的关系，其中没有一项在中国进行。在整个治疗过程中，影响培养转化时间的因素很少被研究。本研究在中国江苏省的四个城市进行。耐多药结核病患者于2011年12月至2014年3月连续入组。计算痰培养转化率并建立Cox比例风险模型。对痰培养转化的影响因素进行了研究。总共纳入了139名具有治疗效果的耐多药结核病患者。转化者到培养转化的中位时间为91.5天（四分位数间距为34.0-110.8天）。多变量分析后，吸烟（HR = 0.44, 95% CI: 0.23-0.83）、饮酒（HR = 0.41, 95% CI: 0.21-0.81）、氧氟沙星耐药（HR = 0.43, 95% CI: 0.24-0.76）和痰涂片分级bbb1 （HR = 0.51, 95% CI: 0.31-0.83）发生培养转化的可能性较低。吸烟、饮酒、对氧氟沙星耐药或涂片等级高的耐多药结核病患者对治疗的反应较小，应仔细随访。
Few prospective cohort studies, none in China, have investigated the relationship between treatment outcomes of multidrug-resistant tuberculosis (MDR-TB) patients and sputum culture conversion. Factors affecting the time of the culture conversion throughout the whole course of the treatment have rarely been investigated. This study was performed in four cities in Jiangsu province, China. MDR-TB patients were consecutively enrolled between December 2011 and March 2014. Rates of sputum culture conversion were calculated and Cox proportional-hazards model was performed. Factors contributing to sputum culture conversion were investigated. In all, 139 MDR-TB patients with treatment outcomes were enrolled. Median time to culture conversion among those who converted was 91.5 days (interquartile range, 34.0–110.8 days). After multivariable analysis, smoking (HR = 0.44; 95% CI: 0.23–0.83), drinking (HR = 0.41; 95% CI: 0.21–0.81), ofloxacin resistance (HR = 0.43; 95% CI: 0.24–0.76) and sputum smear grade > 1 (HR = 0.51; 95% CI: 0.31–0.83) were less likely to have culture conversion. MDR-TB patients who smoke, drink, have ofloxacin resistance, or a high smear grade are less likely to respond to treatment and should be meticulously followed up.
登录
查看更多内容
DOI：
10.5588/ijtld.10.0679
发表时间：
2011-11-01
影响因子：
4
作者：
Qazi, F.;Khan, U.;Khan, A. J.
通讯作者：
Khan, A. J.
影响因子：
24.3
作者：
Leung, Chi C.;Yew, Wing W.;Tam, Cheuk M.
通讯作者：
Tam, Cheuk M.
影响因子：
3.7
作者：
Kanda, Rie;Nagao, Taishi;Nakano, Yasutaka
通讯作者：
Nakano, Yasutaka
DOI：
10.5588/ijtld.16.0096
发表时间：
2016-12-01
影响因子：
4
作者：
Velayutham, B.;Nair, D.;Swaminathan, S.
通讯作者：
Swaminathan, S.
DOI：
10.5588/ijtld.12.0481
发表时间：
2013-04-01
影响因子：
4
作者：
Rodriguez, M.;Monedero, I.;Marcelino, B.
通讯作者：
Marcelino, B.