Advanced human carotid plaque progression correlates positively with flow shear stress using follow-up scan data: an in vivo MRI multi-patient 3D FSI study.
Advanced human carotid plaque progression correlates positively with flow shear stress using follow-up scan data: an in vivo MRI multi-patient 3D FSI study.
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DOI：
10.1016/j.jbiomech.2010.05.018
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发表时间：
2010-09-17
影响因子：
2.4
通讯作者：
Tang, Dalin
中科院分区：
文献类型：
--
作者：
Yang, Chun;Canton, Gador;Yuan, Chun;Ferguson, Marina;Hatsukami, Thomas S.;Tang, Dalin
尽管动脉粥样硬化的发生和早期进展与流动壁切应力（FSS）呈负相关已被广泛接受，但越来越多的证据表明，控制晚期斑块进展的机制尚未得到很好的理解。14名患者使用组织学验证的多重对比磁共振成像（MRI）方案以18个月的间隔扫描2-4次，以获取颈动脉斑块进展数据。形成32个扫描对（基线和随访扫描），切片匹配用于模型构建和分析。构建3D流体-结构相互作用（FSI）模型，并从所有匹配的管腔数据点（每个斑块400-1000个;每个匹配切片100个点）获得斑块壁应力（PWS）和流动剪切应力（FSS），以量化与通过血管壁厚度增加（WTI）测量的斑块进展的相关性。使用随访扫描的FSS和PWS数据，32个扫描对中的21个显示WTI与FSS之间存在显著正相关（正/负/无显著性比率= 21/8/3），32个扫描对中的26个显示WTI与PWS之间存在显著负相关（正/负/无显著性比率= 2/26/4）。所有47个斑块模型的脂质核心结节（n=5294）的平均FSS值为63.5dyn/cm 2，比所有正常血管结节的平均FSS值高45%（n=27553，p<0.00001）。这项密集的FSI研究的结果表明，随访扫描的流动剪切应力与晚期斑块进展呈正相关，这与斑块起始和早期进展中观察到的情况不同。应该注意的是，相关性结果不会自动得出任何因果关系结论。
Although it has been well-accepted that atherosclerosis initiation and early progression correlate negatively with flow wall shear stresses (FSS), increasing evidence suggests mechanisms governing advanced plaque progression are not well understood. Fourteen patients were scanned 2–4 times at 18 month intervals using a histologically validated multi-contrast magnetic resonance imaging (MRI) protocol to acquire carotid plaque progression data. Thirty-two scan pairs (baseline and follow-up scans) were formed with slices matched for model construction and analysis. 3D fluid-structure interaction (FSI) models were constructed and plaque wall stress (PWS) and flow shear stress (FSS) were obtained from all matching lumen data points (400–1000 per plaque; 100 points per matched slice) to quantify correlations with plaque progression measured by vessel wall thickness increase (WTI). Using FSS and PWS data from follow-up scan, 21 out of 32 scan pairs showed a significant positive correlation between WTI and FSS (positive/negative/no significance ratio = 21/8/3), and 26 out of 32 scan pairs showed a significant negative correlation between WTI and PWS (positive/negative/no significance ratio = 2/26/4). The mean FSS value of lipid core nodes (n=5294) from all 47 plaque models was 63.5 dyn/cm2, which was 45% higher than that from all normal vessel nodes (n=27553, p<0.00001)). The results from this intensive FSI study indicate that flow shear stress from follow-up scan correlates positively with advanced plaque progression which is different from what has been observed in plaque initiation and early-stage progression. It should be noted that the correlation results do not automatically lead to any causality conclusions.
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DOI：
10.1115/1.2895545
发表时间：
1993-11-01
影响因子：
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作者：
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DOI：
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发表时间：
2009-06
期刊：
Journal of biomechanical engineering
影响因子：
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作者：
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DOI：
10.1161/01.atv.0000147118.97474.4b
发表时间：
2004-12-01
影响因子：
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作者：
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