Concurrent ocular pain in patients with neurotrophic keratopathy.
Concurrent ocular pain in patients with neurotrophic keratopathy.
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DOI：
10.1016/j.jtos.2021.08.003
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发表时间：
2021-10
期刊：
影响因子：
--
通讯作者：
Hamrah P
中科院分区：
文献类型：
--
作者：
Yavuz Saricay L;Bayraktutar BN;Kenyon BM;Hamrah P
To illustrate that ocular pain may occur in patients with neurotrophic keratopathy (NK) that typically are thought to lack symptoms of discomfort. A subset of these patients may also present with neuropathic corneal pain (NCP). Retrospective case series of 7 stage 1 NK patients who presented with concurrent ocular pain, as confirmed by clinical examination, proparacaine challenge test and in vivo corneal confocal microscopy (IVCM). Records were assessed for results of ocular surface disease index (OSDI), pain on visual analog scale (VAS), ocular pain assessment survey (OPAS), best-corrected visual acuity (BCVA), corneal fluorescein staining (CFS) score, and IVCM findings. IVCM findings were compared to that of 20 healthy reference controls. Mean age of patients was 63.7±11.6 (range 44–76) years and 56.9±8.6 (range 42–74) years in reference controls (p=0.11). At presentation, ocular discomfort was 8.0±1.3 (range 7–10) on VAS and mean OSDI scores were 72.26±6.81 (range 62.50–79.54). Mean BCVA was 20/40, and mean CFS scores were 3.43±0.79 (range 2–4) on the Oxford scale. IVCM analysis showed significant decrease in mean total, main and branch nerve densities in ranges consistent with NK as compared to normal controls (p<0.001 for all), increased dendritiform cell density in three patients (p<0.001), and the presence of micro-neuromas in six of the patients. Patients with neurotrophic keratopathy are thought to present with hypoesthesia. However, nerve damage and inflammation, which play a role in the development of NK may result in the development of chronic ocular pain, such as NCP, resulting in potential under diagnosis of either disease.
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DOI：
10.1016/j.jtos.2016.09.004
发表时间：
2017-01
期刊：
The ocular surface
影响因子：
--
作者：
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通讯作者：
Hamrah P
DOI：
10.1016/j.jtos.2017.09.004
发表时间：
2018-01
期刊：
The ocular surface
影响因子：
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作者：
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影响因子：
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