Movement-generated afference paired with transcranial magnetic stimulation: an associative stimulation paradigm.
Movement-generated afference paired with transcranial magnetic stimulation: an associative stimulation paradigm.
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DOI：
10.1186/1743-0003-11-31
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发表时间：
2014-03-05
影响因子：
5.1
通讯作者：
Pascual-Leone A
中科院分区：
文献类型：
--
作者：
Edwards DJ;Dipietro L;Demirtas-Tatlidede A;Medeiros AH;Thickbroom GW;Mastaglia FL;Krebs HI;Pascual-Leone A
周围神经刺激可以增强或抑制经颅磁刺激（TMS）的诱发反应，这取决于前一个周围神经刺激（PNS）脉冲的潜伏期。同样地，被动运动肢体的体感传入可以以相位依赖的方式短暂地改变皮质运动兴奋性。已知PNS与TMS的重复关联调节皮质运动兴奋性;然而，不知道重复的被动运动关联刺激（MAS）是否具有类似的效果。在一项使用交叉设计的原理验证研究中，7名健康受试者接受了单独的治疗：（1）TMS（静息运动阈值的120%-RMT，桡侧腕屈肌的最佳部位），肌肉处于静息状态;（2）TMS与伸展周期性被动运动期间的周期性被动运动配对（400对，1 Hz），干预顺序随机分配。使用Kolmogorov-Smirnov检验检验正态性，然后使用重复测量ANOVA和Dunnet多重比较检验与干预前基线进行比较。MAS导致运动诱发电位（MEP）幅度在干预过程中进行性显著降低（R2 = 0.6665，P < 0.0001），而单独使用TMS则不明显（R2 = 0.0068，P = 0.641）。仅MAS干预后兴奋性降低持续20 min（0- 10 min = 68.2 ± 4.9%，P < 0.05; 10- 20 min = 73.3 ± 9.7%，P < 0.05）。在健康受试者的初级运动皮层与TMS运动肢体的体感传入的关联可用于调节corticomotor兴奋性，并可能具有治疗意义。
A peripheral nerve stimulus can enhance or suppress the evoked response to transcranial magnetic stimulation (TMS) depending on the latency of the preceding peripheral nerve stimulation (PNS) pulse. Similarly, somatosensory afference from the passively moving limb can transiently alter corticomotor excitability, in a phase-dependent manner. The repeated association of PNS with TMS is known to modulate corticomotor excitability; however, it is unknown whether repeated passive-movement associative stimulation (MAS) has similar effects. In a proof-of-principle study, using a cross-over design, seven healthy subjects received in separate sessions: (1) TMS (120% of the resting motor threshold-RMT, optimal site for Flexor Carpi Radialis) with muscle at rest; (2) TMS paired with cyclic passive movement during extension cyclic passive movement (400 pairs, 1 Hz), with the intervention order randomly assigned. Normality was tested using the Kolmogorov-Smirnov test, then compared to pre-intervention baseline using repeated measures ANOVA with a Dunnet multiple comparisons test. MAS led to a progressive and significant decrease in the motor evoked potential (MEP) amplitude over the intervention (R2 = 0.6665, P < 0.0001), which was not evident with TMS alone (R2 = 0.0068, P = 0.641). Post-intervention excitability reduction, only present with MAS intervention, remained for 20min (0-10min = 68.2 ± 4.9%, P < 0.05; 10-20min = 73.3 ± 9.7%, P < 0.05). The association of somatosensory afference from the moving limb with TMS over primary motor cortex in healthy subjects can be used to modulate corticomotor excitability, and may have therapeutic implications.
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DOI：
10.1109/tnsre.2007.903899
发表时间：
2007-09-01
影响因子：
4.9
作者：
Krebs, Hermano Igo;Volpe, Bruce T.;Hogan, Neville
通讯作者：
Hogan, Neville
影响因子：
9.9
作者：
Gerschlager, W;Siebner, HR;Rothwell, JC
通讯作者：
Rothwell, JC
影响因子：
2
作者：
Di Lazzaro, Vincenzo;Dileone, M.;Tonali, P. A.
通讯作者：
Tonali, P. A.
影响因子：
2.1
作者：
Chye, Lilian;Nosaka, Ken;Thickbroom, Gary
通讯作者：
Thickbroom, Gary
影响因子：
2.5
作者：
Silvanto, Juha;Cattaneo, Zaira;Pascual-Leone, Alvaro
通讯作者：
Pascual-Leone, Alvaro