Differences in pituitary-adrenal reactivity in Black and White men with and without alcohol use disorder.
Differences in pituitary-adrenal reactivity in Black and White men with and without alcohol use disorder.
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DOI：
10.1016/j.psyneuen.2018.10.004
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发表时间：
2019-03
影响因子：
3.7
通讯作者：
Adinoff B
中科院分区：
文献类型：
--
作者：
Price JL;Frazier IR;Lewis B;Walker R;Javors MA;Nixon SJ;Adinoff B
寻求治疗的男性酒精使用障碍（AUD）典型地表现出迟钝的下丘脑-垂体-肾上腺（HPA）轴反应的药物和行为的挑衅在早期阶段的戒酒。独立于酒精，HPA轴反应性的显著沉默也在少数种族（例如黑人）个体中观察到。AUD对少数种族个体HPA轴反应改变的影响尚未探讨。目前的工作代表了对男性样本中种族和AUD状态的二次分析。健康男性对照组（17名白色，7名黑人）和4 - 6周戒断的AUD男性（49名白色，13名黑人）接受心理社会应激源和两种药理学探针[绵羊促肾上腺皮质激素释放激素（oCRH）和促肾上腺皮质激素]，以评估HPA轴反应性。血浆皮质醇和促肾上腺皮质激素（ACTH）进行了评估，在10-20分钟的时间间隔之前和之后的行为和药理学刺激。基础和净综合反应挑衅后进行了分析，以确定潜在的组的差异。童年逆境的措施，也得到了考虑的影响，以前的压力后HPA轴功能。与白色男性相比，无论AUD状态如何，在黑人男性中观察到oCRH诱导的ACTH增加3倍。逆境对这种脑垂体的敏感性产生了抑制作用，只有在黑色控制。调整逆境后，在oCRH后的白色受试者中发现AUD状态对ACTH反应性的显著钝化作用。促肾上腺素给药后无组间差异。为了应对心理社会压力源，相对于白色对照组，患有AUD的男性（白色而不是黑人）经历了预期的皮质醇反应迟钝。相反，患有AUD的黑人男性相对于患有AUD的白色男性表现出更大的皮质醇反应性。与种族相关的HPA轴反应性差异存在于有和没有AUD的男性中。在健康和不健康人群中，酒精使用和/或压力之间关系的解释性生物学机制可能需要在不同种族人群中重新评估。
Treatment-seeking men with alcohol use disorder (AUD) classically exhibit a blunted hypothalamic-pituitary-adrenal (HPA) axis response to pharmacologic and behavioral provocations during the early phases of abstinence from alcohol. Independent of alcohol, a significant muting of HPA axis reactivity is also observed among racial minority (e.g. Black) individuals. The effect of AUD upon the altered HPA axis response of racial minority individuals has not been explored. The current work represents a secondary analysis of race and AUD status among a sample of men. Healthy male controls (17 White, 7 Black) and four-to six-week abstinent men with AUD (49 White, 13 Black) were administered a psychosocial stressor and two pharmacologic probes [ovine corticotropin releasing hormone (oCRH) and cosyntropin] to assess HPA axis reactivity. Plasma cortisol and adrenocorticotropin hormone (ACTH) were assessed at 10–20 minute intervals prior to and following behavioral and pharmacological stimulation. Basal and net-integrated responses following provocations were analyzed to identify potential group differences. A measure of childhood adversity was also obtained to consider the implications of prior stressors upon HPA axis function. A three-fold increase in oCRH-induced ACTH was seen in Black men relative to White men regardless of AUD status. Adversity exerted a dampening effect on this pituitary sensitivity within Black controls only. Adjusted for adversity, a significant blunting effect of AUD status on ACTH reactivity was identified within White participants following oCRH. No group differences were present following cosyntropin administration. In response to the psychosocial stressor, White, but not Black, men with AUD experienced the expected blunting of cortisol reactivity relative to White controls. Rather, Black men with AUD exhibited greater cortisol reactivity relative to White men with AUD. Differences in HPA axis reactivity associated with race were present in men with and without AUD. Explanatory biological mechanisms of the relationship between alcohol use and/or stress, in both healthy and unhealthy populations, may require a reassessment in different racial populations.
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由持续的压力调节的肾上腺皮质敏感性预测了酒精依赖性男性的饮酒强度。
影响因子：
3.7
作者：
Adinoff B;Leonard D;Price J;Javors MA;Walker R;Brown ES;Xiao H;Rao U
通讯作者：
Rao U
DOI：
10.1097/01.alc.0000153544.83656.3c
发表时间：
2005-02-01
影响因子：
3.2
作者：
Breese, GR;Chu, K;Weiss, F
通讯作者：
Weiss, F
影响因子：
3.7
作者：
Chong, Rachel Y.;Uhart, Magdalena;Wand, Gary S.
通讯作者：
Wand, Gary S.
DOI：
10.1097/01.alc.0000158940.05529.0a
发表时间：
2005-04-01
期刊：
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
影响因子：
--
作者：
Adinoff, B;Krebaum, SR;Williams, MJ
通讯作者：
Williams, MJ
影响因子：
2.9
作者：
Chan, Gar Ming;Hoffman, Robert S.;Nelson, Lewis S.
通讯作者：
Nelson, Lewis S.