Neuronal activity (c-Fos) delineating interactions of the cerebral cortex and basal ganglia.
Neuronal activity (c-Fos) delineating interactions of the cerebral cortex and basal ganglia.
复制标题
神经元活动 (c-Fos) 描绘大脑皮层和基底神经节的相互作用
DOI：
10.3389/fnana.2014.00013
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发表时间：
2014
影响因子：
2.9
通讯作者：
Lu J
中科院分区：
文献类型：
--
作者：
Qiu MH;Chen MC;Huang ZL;Lu J
大脑皮层和基底神经节（BG）形成一个神经回路，在帕金森病等疾病中被破坏。我们发现BG中的神经元活动（c-Fos）遵循皮质活动，即，高唤醒状态和低睡眠状态。为了确定皮质活动是否是BG活动所必需的，我们给大鼠注射阿托品以诱导分离状态，导致慢波脑电图，但运动行为过度活跃。阿托品阻断了皮质和BG中的c-Fos表达，尽管皮质下唤醒神经元组和丘脑中的c-Fos表达较高，表明BG激活需要皮质活动。为了确定BG中哪些谷氨酸受体介导皮质输入，我们注射了氯胺酮[N-甲基-d-天冬氨酸（NMDA）受体拮抗剂]和6-氰基-硝基喹喔啉-2，3-二酮（CNQX，一种非NMDA受体拮抗剂）。全身氯胺酮和CNQX给药显示，NMDA受体介导丘脑底核（subthalamic nucleus，NMN）输入到内部苍白球（internal globus pallidus，GPi）和黑质网状部（substantia nigra pars reticulata，SNr），而非NMDA受体介导皮质输入到NMN。这两种类型的谷氨酸受体参与介导皮质输入到纹状体。背侧纹状体（caudoputamen，CPu）多巴胺耗竭6-羟基多巴胺导致活动减少的CPu，苍白球外（GPe），但增加活动的GPi，SNr，和推定的V层神经元在运动皮层。我们的研究结果表明，皮质活动是必要的BG活动，并澄清BG-皮质网络的途径和性质，以及它们在BG疾病的病理生理学中的假定作用。
The cerebral cortex and basal ganglia (BG) form a neural circuit that is disrupted in disorders such as Parkinson’s disease. We found that neuronal activity (c-Fos) in the BG followed cortical activity, i.e., high in arousal state and low in sleep state. To determine if cortical activity is necessary for BG activity, we administered atropine to rats to induce a dissociative state resulting in slow-wave electroencephalography but hyperactive motor behaviors. Atropine blocked c-Fos expression in the cortex and BG, despite high c-Fos expression in the sub-cortical arousal neuronal groups and thalamus, indicating that cortical activity is required for BG activation. To identify which glutamate receptors in the BG that mediate cortical inputs, we injected ketamine [N-methyl-d-aspartate (NMDA) receptor antagonist] and 6-cyano-nitroquinoxaline-2, 3-dione (CNQX, a non-NMDA receptor antagonist). Systemic ketamine and CNQX administration revealed that NMDA receptors mediated subthalamic nucleus (STN) input to internal globus pallidus (GPi) and substantia nigra pars reticulata (SNr), while non-NMDA receptor mediated cortical input to the STN. Both types of glutamate receptors were involved in mediating cortical input to the striatum. Dorsal striatal (caudoputamen, CPu) dopamine depletion by 6-hydroxydopamine resulted in reduced activity of the CPu, globus pallidus externa (GPe), and STN but increased activity of the GPi, SNr, and putative layer V neurons in the motor cortex. Our results reveal that the cortical activity is necessary for BG activity and clarifies the pathways and properties of the BG-cortical network and their putative role in the pathophysiology of BG disorders.
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影响因子：
2.5
作者：
HABER, SN;GROENEWEGEN, HJ;NAUTA, WJH
通讯作者：
NAUTA, WJH
影响因子：
2.5
作者：
Lu, Jun;Nelson, Laura E.;Saper, Clifford B.
通讯作者：
Saper, Clifford B.
影响因子：
3.3
作者：
NAUTA, HJW
通讯作者：
NAUTA, HJW
DOI：
10.1523/jneurosci.3037-10.2010
发表时间：
2010-10-27
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Gompf HS;Mathai C;Fuller PM;Wood DA;Pedersen NP;Saper CB;Lu J
通讯作者：
Lu J
影响因子：
2.5
作者：
SAPER, CB
通讯作者：
SAPER, CB