Dynamic reprogramming of chromatin accessibility during Drosophila embryo development.
Dynamic reprogramming of chromatin accessibility during Drosophila embryo development.
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DOI：
10.1186/gb-2011-12-5-r43
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发表时间：
2011
期刊：
影响因子：
12.3
通讯作者：
Stamatoyannopoulos JA
中科院分区：
文献类型：
--
作者：
Thomas S;Li XY;Sabo PJ;Sandstrom R;Thurman RE;Canfield TK;Giste E;Fisher W;Hammonds A;Celniker SE;Biggin MD;Stamatoyannopoulos JA
The development of complex organisms is believed to involve progressive restrictions in cellular fate. Understanding the scope and features of chromatin dynamics during embryogenesis, and identifying regulatory elements important for directing developmental processes remain key goals of developmental biology. We used in vivo DNaseI sensitivity to map the locations of regulatory elements, and explore the changing chromatin landscape during the first 11 hours of Drosophila embryonic development. We identified thousands of conserved, developmentally dynamic, distal DNaseI hypersensitive sites associated with spatial and temporal expression patterning of linked genes and with large regions of chromatin plasticity. We observed a nearly uniform balance between developmentally up- and down-regulated DNaseI hypersensitive sites. Analysis of promoter chromatin architecture revealed a novel role for classical core promoter sequence elements in directing temporally regulated chromatin remodeling. Another unexpected feature of the chromatin landscape was the presence of localized accessibility over many protein-coding regions, subsets of which were developmentally regulated or associated with the transcription of genes with prominent maternal RNA contributions in the blastoderm. Our results provide a global view of the rich and dynamic chromatin landscape of early animal development, as well as novel insights into the organization of developmentally regulated chromatin features.
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影响因子：
12.3
作者：
Berman BP;Pfeiffer BD;Laverty TR;Salzberg SL;Rubin GM;Eisen MB;Celniker SE
通讯作者：
Celniker SE
DOI：
10.1038/nrg2847
发表时间：
2010-08
期刊：
Nature reviews. Genetics
影响因子：
--
作者：
通讯作者：
--
影响因子：
64.8
作者：
Felsenfeld, G;Groudine, M
通讯作者：
Groudine, M
影响因子：
64.5
作者：
HIROMI, Y;KUROIWA, A;GEHRING, WJ
通讯作者：
GEHRING, WJ
结合位点转换导致密切相关的果蝇物种之间的转录因子结合发生普遍的数量变化。
影响因子：
9.8
作者：
Bradley RK;Li XY;Trapnell C;Davidson S;Pachter L;Chu HC;Tonkin LA;Biggin MD;Eisen MB
通讯作者：
Eisen MB