Evidence of No Association Between Human Papillomavirus and Breast Cancer.
Evidence of No Association Between Human Papillomavirus and Breast Cancer.
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DOI：
10.3389/fonc.2018.00209
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发表时间：
2018
影响因子：
4.7
通讯作者：
Lenz S
中科院分区：
文献类型：
--
作者：
Bønløkke S;Blaakær J;Steiniche T;Høgdall E;Jensen SG;Hammer A;Balslev E;Strube ML;Knakkergaard H;Lenz S
在全球范围内，乳腺癌是妇女最常见的癌症。研究报告说，有宫颈不典型增生病史的妇女患乳腺癌的风险增加。本研究旨在描述人乳头瘤病毒（HPV）在乳腺癌中的流行情况，并探讨既往有宫颈癌的女性与无宫颈癌的女性相比，HPV阳性乳腺癌的风险是否增加。这项病例对照研究确定了193名丹麦妇女在奥胡斯大学医院或哥本哈根大学医院Herlev诊断为乳腺癌（1998-2012）。病例为93例乳腺癌前宫颈上皮内瘤变3级或更差（CIN 3+）的女性。对照组为100名既往无宫颈发育不良的妇女。使用SPF 10 PCR-DEIA-LiPA 25和内部半定量PCR检测进行HPV检测和基因分型。对于检测，乳腺癌的总体HPV患病率为1.55%（95% CI 0.32-4.48）和0.52%（95% CI 0.01-2.85）。病例组和对照组的HPV感染率无差异（2.15 vs. 1.00%，p = 0.61和1.08 vs. 0.00%，p = 0.48）。宫颈上皮内瘤样病变3+组HPV感染率为94.62%（95%CI 0.88-0.98）。测定之间的一致性为98.60%。HPV在乳腺癌中的患病率非常低，表明HPV与乳腺癌之间没有病因学相关性。
Globally, breast cancer is the most frequent cancer among women. Studies reported an increased risk of breast cancer among women with prior cervical dysplasia. This study aimed to describe the prevalence of human papillomavirus (HPV) in breast cancer and explore if women with prior cervical neoplasia carry an increased risk of HPV-positive breast cancer compared to women without. This case–control study identified 193 Danish women diagnosed with breast cancer (1998–2012) at Aarhus University Hospital or Copenhagen University Hospital Herlev. Cases were 93 women with cervical intraepithelial neoplasia grade 3 or worse (CIN3+) prior to breast cancer. Controls were 100 women without prior cervical dysplasia. HPV testing and genotyping were done using SPF10 PCR-DEIA-LiPA25 and an in-house semi-Q-PCR assay. Overall HPV prevalence in breast cancer for the assays was 1.55% (95% CI 0.32–4.48) and 0.52% (95% CI 0.01–2.85). There was no difference in HPV prevalence between cases and controls (2.15 vs. 1.00%, p = 0.61 and 1.08 vs. 0.00%, p = 0.48). HPV prevalence in CIN3+ was 94.62% (95% CI 0.88–0.98). Concordance between the assays was 98.60%. HPV prevalence in breast cancer is very low suggesting no etiological correlation between HPV and breast cancer.
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影响因子：
1.8
作者：
Glenn, Wendy K;Whitaker, Noel J;Lawson, James S
通讯作者：
Lawson, James S
人类乳腺肿瘤中生物致癌物质的多重PCR/质谱筛查
影响因子：
8.8
作者：
Peng, Junping;Wang, Ting;Jin, Qi
通讯作者：
Jin, Qi
影响因子：
7.4
作者：
de Villiers, EM;Sandstrom, RE;zur Hausen, H;Buck, CE
通讯作者：
Buck, CE
影响因子：
4.7
作者：
Lawson JS;Glenn WK;Salyakina D;Clay R;Delprado W;Cheerala B;Tran DD;Ngan CC;Miyauchi S;Karim M;Antonsson A;Whitaker NJ
通讯作者：
Whitaker NJ
影响因子：
4.7
作者：
Lawson JS;Glenn WK;Salyakina D;Delprado W;Clay R;Antonsson A;Heng B;Miyauchi S;Tran DD;Ngan CC;Lutze-Mann L;Whitaker NJ
通讯作者：
Whitaker NJ