Mammalian Intestinal Development and Differentiation-The State of the Art.
Mammalian Intestinal Development and Differentiation-The State of the Art.
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哺乳动物肠道发育和分化——最先进的技术。
DOI：
10.1016/j.jcmgh.2023.07.011
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发表时间：
2023
影响因子：
7.2
通讯作者：
Kaestner, Klaus H.
中科院分区：
文献类型：
--
作者：
Kolev, Hannah M.;Kaestner, Klaus H.
哺乳动物肠道的发育，从其最早的起源，从原肠发育过程中形态一致的内胚层细胞片到对有机体生命至关重要的复杂器官系统，是一个真正令人着迷的过程。在妊娠中期，内胚层来源的上皮和中胚层来源的间质之间的相互作用使绒毛化，或将径向对称的假复层上皮转化为隐窝和绒毛的功能细分。一旦建立了成熟的隐窝绒毛轴，新的上皮细胞的增殖和分化就会在整个生命过程中继续下去。空间定位的信号包括无翼和Int-1、成纤维细胞生长因子和河马系统等，确保新细胞在隐窝中持续出生。当细胞离开隐窝时，骨形态发生蛋白信号的梯度限制了增殖，以允许指定多种成熟细胞类型。第一个主要的分化决定依赖于Notch信号，它指定上皮细胞分为吸收和分泌两种谱系。通过一个复杂的转录因子网络，分泌谱系进一步细分为盘状细胞、杯状细胞、簇状细胞和肠内分泌细胞。尽管一些信号分子是由上皮细胞产生的，但关键成分来自称为端细胞的专门的隐窝相邻间充质细胞，其标记为Forkhead box L1、Gli家族锌指1和血小板衍生生长因子受体α。这些过程的关键性质被大量的肠道疾病所证明，如结直肠癌、短肠综合征和炎症性肠病，所有这些都反映了肠道的发育和/或分化的扰动。
The development of the mammalian intestine, from its earliest origins as a morphologically uniform sheet of endoderm cells during gastrulation into the complex organ system that is essential for the life of the organism, is a truly fascinating process. During midgestation development, reciprocal interactions between endoderm-derived epithelium and mesoderm-derived mesenchyme enable villification, or the conversion of a radially symmetric pseudostratified epithelium into the functional subdivision of crypts and villi. Once a mature crypt–villus axis is established, proliferation and differentiation of new epithelial cells continue throughout life. Spatially localized signals including the wingless and Int-1, fibroblast growth factor, and Hippo systems, among others, ensure that new cells are being born continuously in the crypt. As cells exit the crypt compartment, a gradient of bone morphogenetic protein signaling limits proliferation to allow for the specification of multiple mature cell types. The first major differentiation decision is dependent on Notch signaling, which specifies epithelial cells into absorptive and secretory lineages. The secretory lineage is subdivided further into Paneth, goblet, tuft, and enteroendocrine cells via a complex network of transcription factors. Although some of the signaling molecules are produced by epithelial cells, critical components are derived from specialized crypt-adjacent mesenchymal cells termed telocytes, which are marked by Forkhead box l1, GLI Family Zinc Finger 1, and platelet-derived growth factor receptor α. The crucial nature of these processes is evidenced by the multitude of intestinal disorders such as colorectal cancer, short-bowel syndrome, and inflammatory bowel disease, which all reflect perturbations of the development and/or differentiation of the intestine.
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影响因子：
5.3
作者：
Cantarero Carmona I;Luesma Bartolomé MJ;Junquera Escribano C
通讯作者：
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影响因子：
64.8
作者：
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通讯作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
3.7
作者：
Cai Y;Wang W;Liang H;Sun L;Teitelbaum DH;Yang H
通讯作者：
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