High expression of Lewis y antigen and CD44 is correlated with resistance to chemotherapy in epithelial ovarian cancers.
High expression of Lewis y antigen and CD44 is correlated with resistance to chemotherapy in epithelial ovarian cancers.
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Lewis y抗原和CD44的高表达与上皮性卵巢癌化疗耐药相关
DOI：
10.1371/journal.pone.0057250
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Lin B
中科院分区：
文献类型：
--
作者：
Hu Z;Gao J;Zhang D;Liu Q;Yan L;Gao L;Liu J;Liu D;Zhang S;Lin B
目的检测卵巢上皮性癌组织中刘易斯y抗原和CD 44抗原的表达，探讨其与化疗疗效的关系。方法对34例卵巢癌化疗耐药患者、6例部分敏感患者和52例药物敏感患者共92例进行分析。结果耐药组刘易斯y抗原和CD 44抗原表达率明显高于部分敏感组和敏感组。卵巢癌组织中CD44和刘易斯y抗原的表达、手术分期、残留肿瘤大小是卵巢癌化疗耐药的独立危险因素。结论刘易斯y和CD 44抗原的高表达是卵巢癌化疗耐药的重要危险因素。
Objectives To measure Lewis y antigen and CD44 antigen expression in epithelial ovarian carcinoma and to correlate the levels of these antigens with clinical response to chemotherapy. Methods The study cases included 34 cases of ovarian carcinoma with resistance to chemotherapeutic drugs, 6 partially drug-sensitive cases, and 52 drug-sensitive cases (92 total). Results The rates of expression of Lewis y antigen and CD44 antigen were significantly greater in the drug-resistant group than that in the partially-sensitive or sensitive groups. Surgical stage, residual tumor size and expression of CD44 and Lewis y antigen in ovarian carcinoma tissues were independent risk factors for chemotherapeutic drug resistance. Conclusions Over-expression of Lewis y and CD44 antigen are strong risk factors for chemotherapeutic drug resistance in ovarian carcinoma patients.
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影响因子：
5.6
作者：
Wang Y;Liu J;Lin B;Wang C;Li Q;Liu S;Yan L;Zhang S;Iwamori M
通讯作者：
Iwamori M
DOI：
10.1158/1078-0432.ccr-10-2289
发表时间：
2011-04-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Santiskulvong C;Konecny GE;Fekete M;Chen KY;Karam A;Mulholland D;Eng C;Wu H;Song M;Dorigo O
通讯作者：
Dorigo O
影响因子：
4.8
作者：
Bourguignon, LYW;Singleton, PA;Diedrich, F
通讯作者：
Diedrich, F
影响因子：
9.7
作者：
Ohashi, Rina;Takahashi, Fumiyuki;Takahashi, Kazuhisa
通讯作者：
Takahashi, Kazuhisa
影响因子：
9.7
作者：
Yap, Yeannie Hui-Yeng;Say, Yee-How
通讯作者：
Say, Yee-How