Exaptive origins of regulated mRNA decay in eukaryotes.
Exaptive origins of regulated mRNA decay in eukaryotes.
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DOI：
10.1002/bies.201600100
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发表时间：
2016-09
期刊：
影响因子：
4
通讯作者：
Makeyev, Eugene V.
中科院分区：
文献类型：
--
作者：
Hamid, Fursham M.;Makeyev, Eugene V.
真核基因的表达被广泛地控制在mRNA稳定的水平上，这种调控的机制与古生物和细菌的基因表达有显着的不同。我们提出了两种这样的机制，即无义介导的衰退(NMD)和CCCH型锌指RNA结合蛋白导致的基序特异性转录失稳，这两种机制起源于细胞对RNA病原体的防御。原始真核生物可能已经使用了mRNA周转途径的这些分支与RNA干扰一起来区分它们自己的信息与RNA病毒和逆转座子元件的信息。我们进一步假设，随后出现的“专业”先天免疫系统和适应性免疫系统允许NMD和Motif触发的机制有效地改变用途，以调节内源性细胞转录。这一情景解释了真核生物中典型的mRNA失稳途径的迅速出现，并认为这一谱系中转录后基因调控的其他方面可能是通过类似的突触途径衍生出来的。
Eukaryotic gene expression is extensively controlled at the level of mRNA stability and the mechanisms underlying this regulation are markedly different from their archaeal and bacterial counterparts. We propose that two such mechanisms, nonsense‐mediated decay (NMD) and motif‐specific transcript destabilization by CCCH‐type zinc finger RNA‐binding proteins, originated as a part of cellular defense against RNA pathogens. These branches of the mRNA turnover pathway might have been used by primeval eukaryotes alongside RNA interference to distinguish their own messages from those of RNA viruses and retrotransposable elements. We further hypothesize that the subsequent advent of “professional” innate and adaptive immunity systems allowed NMD and the motif‐triggered mechanisms to be efficiently repurposed for regulation of endogenous cellular transcripts. This scenario explains the rapid emergence of archetypical mRNA destabilization pathways in eukaryotes and argues that other aspects of post‐transcriptional gene regulation in this lineage might have been derived through a similar exaptation route.
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DOI：
10.1126/science.aaf5573
发表时间：
2016-08-05
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Abudayyeh OO;Gootenberg JS;Konermann S;Joung J;Slaymaker IM;Cox DB;Shmakov S;Makarova KS;Semenova E;Minakhin L;Severinov K;Regev A;Lander ES;Koonin EV;Zhang F
通讯作者：
Zhang F
影响因子：
29.7
作者：
Boehm T;McCurley N;Sutoh Y;Schorpp M;Kasahara M;Cooper MD
通讯作者：
Cooper MD
DOI：
10.1016/j.bbagrm.2013.02.003
发表时间：
2013-06
影响因子：
4.7
作者：
Brooks, Seth A.;Blackshear, Perry J.
通讯作者：
Blackshear, Perry J.
影响因子：
13.8
作者：
Czech B;Hannon GJ
通讯作者：
Hannon GJ
影响因子：
3.7
作者：
Abernathy, Emma;Glaunsinger, Britt
通讯作者：
Glaunsinger, Britt