Advances in Optical Detection of Human-Associated Pathogenic Bacteria.
Advances in Optical Detection of Human-Associated Pathogenic Bacteria.
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DOI：
10.3390/molecules25225256
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发表时间：
2020-11-11
期刊：
影响因子：
--
通讯作者：
Mahadevan-Jansen A
中科院分区：
文献类型：
--
作者：
Locke A;Fitzgerald S;Mahadevan-Jansen A
细菌感染是一种全球性负担，每年导致许多医院就诊和死亡。多重耐药细菌的出现大大增加了这一负担。因此，临床上需要在细菌的天然状态或无培养环境中快速且准确地检测和鉴定细菌。目前的诊断技术在检测培养阴性的细菌方面缺乏速度和有效性，也缺乏体内检测的选择。细菌的光学检测提供了克服这些障碍的潜力，通过提供各种平台，可以快速检测细菌，最少的样品制备，并且在某些情况下，直接从患者液体或甚至在体内无培养。这些模态包括红外、拉曼和荧光光谱，沿着光学相干断层扫描、干涉、偏振和激光散斑。然而，这些技术并非没有它们自己的一组限制。本文综述了利用这些光学工具进行快速细菌检测和鉴定的优点和缺点。
Bacterial infection is a global burden that results in numerous hospital visits and deaths annually. The rise of multi-drug resistant bacteria has dramatically increased this burden. Therefore, there is a clinical need to detect and identify bacteria rapidly and accurately in their native state or a culture-free environment. Current diagnostic techniques lack speed and effectiveness in detecting bacteria that are culture-negative, as well as options for in vivo detection. The optical detection of bacteria offers the potential to overcome these obstacles by providing various platforms that can detect bacteria rapidly, with minimum sample preparation, and, in some cases, culture-free directly from patient fluids or even in vivo. These modalities include infrared, Raman, and fluorescence spectroscopy, along with optical coherence tomography, interference, polarization, and laser speckle. However, these techniques are not without their own set of limitations. This review summarizes the strengths and weaknesses of utilizing each of these optical tools for rapid bacteria detection and identification.
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抗药性金黄色葡萄球菌菌株与拉曼微光谱法揭示了不同的生化特征。
影响因子：
5.3
作者：
Ayala OD;Wakeman CA;Pence IJ;Gaddy JA;Slaughter JC;Skaar EP;Mahadevan-Jansen A
通讯作者：
Mahadevan-Jansen A
影响因子：
--
作者：
Almarashi, Jamal F. M.;Kapel, Natalia;Telle, Helmut H.
通讯作者：
Telle, Helmut H.
影响因子：
4.9
作者：
Bastert, J;Korting, HC;Schmalreck, AF
通讯作者：
Schmalreck, AF
DOI：
10.1039/c7ay00128b
发表时间：
2017-03-28
期刊：
Analytical methods : advancing methods and applications
影响因子：
--
作者：
Ayala OD;Wakeman CA;Pence IJ;O'Brien CM;Werkhaven JA;Skaar EP;Mahadevan-Jansen A
通讯作者：
Mahadevan-Jansen A
影响因子：
3.5
作者：
Bouhedja, W;Sockalingum, GD;Manfait, M
通讯作者：
Manfait, M