Amygdala response to mother.
Amygdala response to mother.
复制标题
DOI：
10.1111/j.1467-7687.2011.01128.x
复制
发表时间：
2012-05
影响因子：
3.7
通讯作者：
Humphreys KL
中科院分区：
文献类型：
--
作者：
Tottenham N;Shapiro M;Telzer EH;Humphreys KL
在高级物种中，如人类，照顾者，通常是母亲，是发育过程中最有力的刺激之一。母亲和其他成年人之间的区别是在生命的早期就学会的，并导致了孩子的许多行为，最明显的是母亲的接近和陌生人的警惕。本研究探讨了母亲刺激对25名发育中的儿童（n=13）和青少年（n=12）杏仁核活动和相关回路的影响，以及该回路如何与依恋相关行为相关。结果表明，母亲的刺激是特别有效的招聘活动在左背杏仁核，并在此杏仁核区域的活动表现出增加的功能连接与评价和运动区域在观看母亲的刺激。左侧背侧杏仁核活动和相关杏仁核-皮质功能连接的增加与增加的母亲接近行为相关，这是通过扫描仪内行为反应和扫描仪外儿童报告测量的。此外，年龄相关的杏仁核活动的变化，以非母亲统计介导的发育典型下降，在陌生人的警惕性在这一时期看到的。这些结果表明，母亲诱导的行为制定了母亲的影响杏仁皮质回路在儿童和青少年时期。
In altricial species, like the human, the caregiver, very often the mother, is one of the most potent stimuli during development. The distinction between mothers and other adults is learned early in life and results in numerous behaviors in the child, most notably mother-approach and stranger-wariness. The current study examined the influence of the maternal stimulus on amygdala activity and related circuitry in twenty-five developing children (n=13) and adolescents (n=12), and how this circuitry was associated with attachment-related behaviors. Results indicated that maternal stimuli were especially effective in recruiting activity in the left dorsal amygdala, and activity in this amygdala region showed increased functional connectivity with evaluative and motor regions during viewing of maternal stimuli. Increases in this left dorsal amygdala activity and related amygdala-cortical functional connectivity were associated with increased mother-approach behaviors as measured by in-scanner behavioral responding and out-of-scanner child-report. Moreover, age-related changes in amygdala activity to non-mothers statistically mediated the developmentally typical decline in stranger wariness seen across this period. These results suggest that mother-induced behaviors are enacted by maternal influence on amygdala-cortical circuitry during childhood and adolescence.
登录
查看更多内容
影响因子：
7.6
作者：
BARON, RM;KENNY, DA
通讯作者：
KENNY, DA
影响因子：
2.5
作者：
Arsalidou, Marie;Barbeau, Emmanuel J.;Taylor, Margot J.
通讯作者：
Taylor, Margot J.
影响因子：
2.5
作者：
HUMPHREY, T
通讯作者：
HUMPHREY, T
影响因子：
3.3
作者：
BOWLBY, J
通讯作者：
BOWLBY, J
影响因子：
17.7
作者：
Kleinhans, Natalia M.;Johnson, L. Clark;Aylward, Elizabeth
通讯作者：
Aylward, Elizabeth