Genetic variants in 5-HTTLPR, BDNF, HTR1A, COMT, and FKBP5 and risk for treated depression after cancer diagnosis.
Genetic variants in 5-HTTLPR, BDNF, HTR1A, COMT, and FKBP5 and risk for treated depression after cancer diagnosis.
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DOI：
10.1002/da.22660
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发表时间：
2017-09
影响因子：
7.4
通讯作者：
Dalton SO
中科院分区：
文献类型：
--
作者：
Suppli NP;Bukh JD;Moffitt TE;Caspi A;Johansen C;Tjønneland A;Kessing LV;Dalton SO
基因-环境相互作用在抑郁症发病机制中的作用尚不清楚。以前的研究解决了许多特定遗传变异携带者在童年逆境和压力生活事件后抑郁的脆弱性;然而，个体遗传变异的重要性，与它们相互作用的环境暴露以及这些相互作用所传达的风险程度仍然难以捉摸。我们纳入了7，320名在前瞻性饮食，癌症和健康研究中确定的第一原发性癌症患者，这是一项仅暴露的队列研究。在癌症诊断时，个体的平均年龄为68岁（第5、95届世界杯：58、78岁）。使用考克斯回归模型和累积发病率图，我们分析了5-HTTLPR、BDNF、HTR 1A、COMT和FKBP 5的遗传变异与抗抑郁药的使用以及癌症诊断后抑郁症的医院接触之间的关联。总的来说，我们没有观察到统计学上显著的相关性，使用抗抑郁药的非显著风险比估计为0.95-1.07。这项针对老年人的研究表明，所研究的遗传变异不太可能与癌症诊断后的抑郁症有临床相关性。年轻个体中基因与环境相互作用的机制可能有所不同，我们建议在将我们的结果外推到早期生活压力时谨慎。然而，本研究的结论可能是普遍的老年人暴露于其他压力的生活事件。
The role of gene–environment interactions in the pathogenesis of depression is unclear. Previous studies addressed vulnerability for depression after childhood adversity and stressful life events among carriers of numerous specific genetic variants; however, the importance of individual genetic variants, the environmental exposures with which they interact, and the magnitude of the risk conveyed by these interactions remain elusive. We included 7,320 people with a first primary cancer identified in the prospective Diet, Cancer and Health study in an exposed-only cohort study. The mean age of the individuals was 68 years (5th, 95th percentiles: 58, 78) at cancer diagnosis. Using Cox regression models and cumulative incidence plots, we analyzed the associations between genetic variants in 5-HTTLPR, BDNF, HTR1A, COMT, and FKBP5 and use of antidepressants as well as hospital contact for depression after diagnosis of cancer. Overall, we observed no statistically significant associations, with nonsignificant hazard ratio estimates for use of antidepressants of 0.95–1.07. This study of elderly people indicates that it is unlikely that the investigated genetic variants are clinically relevantly associated with depression after diagnosis of cancer. The mechanisms for gene–environment interactions in younger individuals are probably different, and we advise caution in extrapolating our results to early life stress. However, conclusion from the present study might be generalizable to elderly persons exposed to other stressful life events.
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DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM
DOI：
10.1186/1745-0179-5-4
发表时间：
2009-02-12
期刊：
Clinical practice and epidemiology in mental health : CP & EMH
影响因子：
--
作者：
Bock, Camilla;Bukh, Jens Drachmann;Kessing, Lars Vedel
通讯作者：
Kessing, Lars Vedel
影响因子：
30.8
作者：
Binder, EB;Salyakina, D;Muller-Myhsok, B
通讯作者：
Muller-Myhsok, B
影响因子：
9.3
作者：
Hosang GM;Shiles C;Tansey KE;McGuffin P;Uher R
通讯作者：
Uher R
影响因子：
3.8
作者：
Dunn EC;Brown RC;Dai Y;Rosand J;Nugent NR;Amstadter AB;Smoller JW
通讯作者：
Smoller JW