Emerging trends in the pathophysiology of lymphatic contractile function.
Emerging trends in the pathophysiology of lymphatic contractile function.
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DOI：
10.1016/j.semcdb.2015.01.005
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发表时间：
2015-02
影响因子：
7.3
通讯作者：
Muthuchamy, Mariappan
中科院分区：
文献类型：
--
作者：
Chakraborty, Sanjukta;Davis, Michael J.;Muthuchamy, Mariappan
淋巴收缩功能障碍是影响全世界数百万人的许多病理学的核心。由于其在炎症过程中的关键作用，功能失调的淋巴系统也会损害免疫反应，进一步加剧许多炎症相关疾病。尽管淋巴液的运输完成了重要的生理功能，但对淋巴系统收缩机制的完整理解远远落后于对血管系统的理解。然而，最近的研究集中在淋巴收缩功能的生理和病理生理方面的不同机制上。这篇综述总结了那些新兴的范式，脱落的一些新的见解收缩生理学的正常以及不同的疾病状态下的血管。此外，本次审查强调了最近取得的进展，在我们的理解各种收缩参数和调节因素，有助于正常运作的血管。
Lymphatic contractile dysfunction is central to a number of pathologies that affect millions of people worldwide. Due to its critical role in the process of inflammation, a dysfunctional lymphatic system also compromises the immune response, further exacerbating a number of inflammation related diseases. Despite the critical physiological functions accomplished by the transport of lymph, a complete understanding of the contractile machinery of the lymphatic system lags far behind that of the blood vasculature. However, there has been a surge of recent research focusing on different mechanisms that underlie both physiological and pathophysiological aspects of lymphatic contractile function. This review summarizes those emerging paradigms that shed some novel insights into the contractile physiology of the lymphatics in normal as well as different disease states. In addition, this review emphasizes the recent progress made in our understanding of various contractile parameters and regulatory elements that contribute to the normal functioning of the lymphatics.
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影响因子：
32.4
作者：
Angeli, V;Llodrá, J;Randolph, GJ
通讯作者：
Randolph, GJ
影响因子：
3.7
作者：
Blum KS;Karaman S;Proulx ST;Ochsenbein AM;Luciani P;Leroux JC;Wolfrum C;Detmar M
通讯作者：
Detmar M
影响因子：
2.4
作者：
Chakraborty, Sanjukta;Nepiyushchikh, Zhanna;Muthuchamy, Mariappan
通讯作者：
Muthuchamy, Mariappan
影响因子：
--
作者：
BENOIT, JN;ZAWIEJA, DC
通讯作者：
ZAWIEJA, DC
影响因子：
--
作者：
BENOIT, JN;ZAWIEJA, DC;GRANGER, HJ
通讯作者：
GRANGER, HJ