Oligodendrocyte dynamics dictate cognitive performance outcomes of working memory training in mice.
Oligodendrocyte dynamics dictate cognitive performance outcomes of working memory training in mice.
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DOI：
10.1038/s41467-023-42293-4
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发表时间：
2023-10-14
影响因子：
16.6
通讯作者：
Richardson, William D.
中科院分区：
文献类型：
--
作者：
Shimizu, Takahiro;Nayar, Stuart G.;Swire, Matthew;Jiang, Yi;Grist, Matthew;Kaller, Malte;Baptista, Cassandra Sampaio;Bannerman, David M.;Johansen-Berg, Heidi;Ogasawara, Katsutoshi;Tohyama, Koujiro;Li, Huiliang;Richardson, William D.
先前的研究表明，运动技能学习刺激并需要成年小鼠大脑中髓鞘少突胶质细胞（OLs）的生成，这些细胞来自它们的前体细胞（OLPs）。在本研究中，我们使用t形迷宫和径向臂迷宫任务来研究非运动学习和认知是否也需要OL的产生。我们发现迷宫训练刺激成年雄性小鼠内侧前额叶皮层（mPFC）、胼胝体前部（genu）、丘脑背侧和海马形成的OLP增殖和OL生成；髓鞘的形成也在膝内受到刺激。Myrf条件敲除小鼠的OL分化和新髓鞘形成的遗传阻断严重损害了训练诱导的迷宫表现的改善。我们发现单个野生型小鼠的表现与训练过程中OLP增殖和OL生成的规模呈正相关，但与mPFC中c-Fos+神经元的数量或强度无关，这强调了OL谱系细胞在认知加工中的重要作用。少突胶质细胞（OLs）如何以及在多大程度上促进学习和认知尚不清楚。在这里，作者表明，小鼠在依赖工作记忆的认知任务中的表现取决于OL的产生，并与训练过程中OL前体和OL产生的数量成正比。
Previous work has shown that motor skill learning stimulates and requires generation of myelinating oligodendrocytes (OLs) from their precursor cells (OLPs) in the brains of adult mice. In the present study we ask whether OL production is also required for non-motor learning and cognition, using T-maze and radial-arm-maze tasks that tax spatial working memory. We find that maze training stimulates OLP proliferation and OL production in the medial prefrontal cortex (mPFC), anterior corpus callosum (genu), dorsal thalamus and hippocampal formation of adult male mice; myelin sheath formation is also stimulated in the genu. Genetic blockade of OL differentiation and neo-myelination in Myrf conditional-knockout mice strongly impairs training-induced improvements in maze performance. We find a strong positive correlation between the performance of individual wild type mice and the scale of OLP proliferation and OL generation during training, but not with the number or intensity of c-Fos+ neurons in their mPFC, underscoring the important role played by OL lineage cells in cognitive processing. How and to what extent oligodendrocytes (OLs) contribute to learning and cognition is not well understood. Here, the authors show that the performance of mice in working memory-dependent cognitive tasks depends on OL genesis and is proportional to the number of OL precursors and OLs generated during training.
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细胞外田地和电流的起源-EEG，ECOG，LFP和尖峰。
DOI：
10.1038/nrn3241
发表时间：
2012-05-18
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Buzsáki G;Anastassiou CA;Koch C
通讯作者：
Koch C
影响因子：
25
作者：
Bacmeister, Clara M.;Huang, Rongchen;Osso, Lindsay A.;Thornton, Michael A.;Conant, Lauren;Chavez, Anthony;Poleg-Polsky, Alon;Hughes, Ethan G.
通讯作者：
Hughes, Ethan G.
影响因子：
64.8
作者：
Bergles, DE;Roberts, JDB;Jahr, CE
通讯作者：
Jahr, CE
影响因子：
2.7
作者：
Benjamini, Yoav;Krieger, Abba M.;Yekutieli, Daniel
通讯作者：
Yekutieli, Daniel
影响因子：
24.8
作者：
D'Esposito M;Postle BR
通讯作者：
Postle BR