Paracrine signaling mediated at cell-cell contacts.
Paracrine signaling mediated at cell-cell contacts.
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DOI:
10.1002/bies.201400122
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发表时间:
2015-01
期刊:
影响因子:
4
通讯作者:
Kornberg, Thomas B.
中科院分区:
文献类型:
--
作者:
Roy, Sougata;Kornberg, Thomas B.
Recent findings in several organ systems show that cytoneme-mediated signaling transports signaling proteins along cellular extensions and targets cell-to-cell exchanges to synaptic contacts. This mechanism of paracrine signaling may be a general one that is used by many (or all) cell types in many (or all) organs. We briefly review these findings in this perspective. We also describe the properties of several signaling systems that have previously been interpreted to support a passive diffusion mechanism of signaling protein dispersion, but can now be understood in the context of the cytoneme mechanism.
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