A novel tick-borne phlebovirus, closely related to severe fever with thrombocytopenia syndrome virus and Heartland virus, is a potential pathogen.
A novel tick-borne phlebovirus, closely related to severe fever with thrombocytopenia syndrome virus and Heartland virus, is a potential pathogen.
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一种新型蜱传白斑病毒，与严重发热伴血小板减少综合征病毒和哈特兰病毒密切相关，是一种潜在的病原体
DOI：
10.1038/s41426-018-0093-2
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发表时间：
2018-05-25
影响因子：
13.2
通讯作者：
Deng F
中科院分区：
文献类型：
--
作者：
Shen S;Duan X;Wang B;Zhu L;Zhang Y;Zhang J;Wang J;Luo T;Kou C;Liu D;Lv C;Zhang L;Chang C;Su Z;Tang S;Qiao J;Moming A;Wang C;Abudurexiti A;Wang H;Hu Z;Zhang Y;Sun S;Deng F
近年来，蜱传病毒性疾病因其发病率不断上升以及对人类健康的威胁而备受关注。严重发热伴血小板减少综合征白静脉病毒（SFTSV）和哈特兰病毒（HRTV）最近在亚洲和美国分别被鉴定为蜱传白静脉病毒（TBPV），并且与具有相似临床表现的严重人类疾病相关。在这项研究中，我们首次从中国新疆省的坚果中鉴定和分离出一种名为古尔图病毒（GTV）的新型 TBPV，此前该地区从未发现过 TBPV。基因组序列和系统发育分析表明，GTV与SFTSV和HRTV密切相关，属于布尼亚病毒目苯病毒科白蛉病毒属的成员。对GTV特性的体外和体内研究表明，它能够感染动物和人类细胞系，并且可以抑制I型干扰素信号传导，与SFTSV类似，GTV核蛋白（NP）可以通过取代SFTSV NP来挽救SFTSV复制，并且GTV感染可以引起小鼠的病理病变。此外，一项血清学调查从古尔图县居民的血清样本中发现了针对GTV的抗体，其中三份含有中和抗体，表明GTV可以感染人类。我们的研究结果表明，这种病毒是一种对动物和人类构成威胁的潜在病原体。建议在新疆及其他地区开展 GTV 的进一步研究和监测。
Tick-borne viral diseases have attracted much attention in recent years because of their increasing incidence and threat to human health. Severe fever with thrombocytopenia syndrome phlebovirus (SFTSV) and Heartland virus (HRTV) were recently identified as tick-borne phleboviruses (TBPVs) in Asia and the United States, respectively, and are associated with severe human diseases with similar clinical manifestations. In this study, we report the first identification and isolation of a novel TBPV named Guertu virus (GTV) fromDermacentor nuttalliticks in Xinjiang Province, China, where TBPVs had not been previously discovered. Genome sequence and phylogenetic analyses showed that GTV is closely related to SFTSV and HRTV and was classified as a member of the genusPhlebovirus, familyPhenuiviridae, orderBunyavirales. In vitro and in vivo investigations of the properties of GTV demonstrated that it was able to infect animal and human cell lines and can suppress type I interferon signaling, similar to SFTSV, that GTV nucleoprotein (NP) can rescue SFTSV replication by replacing SFTSV NP, and that GTV infection can cause pathological lesions in mice. Moreover, a serological survey identified antibodies against GTV from serum samples of individuals living in Guertu County, three of which contained neutralizing antibodies, suggesting that GTV can infect humans. Our findings suggested that this virus is a potential pathogen that poses a threat to animals and humans. Further studies and surveillance of GTV are recommended to be carried out in Xinjiang Province as well as in other locations.
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影响因子：
3.8
作者：
Chen, Xiao-Ping;Cong, Mei-Li;Zhang, Yong-Zhen
通讯作者：
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5.4
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影响因子：
5.2
作者：
Matsuno K;Orba Y;Maede-White K;Scott D;Feldmann F;Liang M;Ebihara H
通讯作者：
Ebihara H
影响因子：
28.2
作者：
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通讯作者：
Cao, Wu-Chun
影响因子：
3.8
作者：
Hewson, R;Gmyl, A;Clegg, C
通讯作者：
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