Identification of antigenic determinants on insulin recognized by monoclonal antibodies.
Identification of antigenic determinants on insulin recognized by monoclonal antibodies.
复制标题
单克隆抗体识别的胰岛素抗原决定簇的鉴定。
DOI：
10.1016/0161-5890(86)90142-2
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发表时间：
1986
影响因子：
3.6
通讯作者：
P. Underwood
中科院分区：
文献类型：
--
作者：
D. Rathjen;P. Underwood
The specificities of nine monoclonal antibodies raised to bovine insulin were investigated. The probable binding sites of the antibodies were determined by correlation of cross-reactivity with heterologous insulins and amino acid differences in the primary structures. Most antibodies recognized topographic determinants composed of both A- and B-chain residues but were capable of binding either one or both free chains independently. Only one antibody was completely conformation-dependent. A number of antibodies showed heteroclitic binding to particular insulin variants. All the antibodies were autoreactive in that they recognized rat insulin which has the same primary sequence as the mouse molecule.
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DOI：
--
发表时间：
1982
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Smith-Gill,SJ;Wilson,AC;Potter,M;Prager,EM;Feldmann,RJ;Mainhart,CR
通讯作者：
Mainhart,CR
对兔细胞色素c的自身抗原反应。
影响因子：
5.4
作者：
Cooper,HM;Klinman,NR;Paterson,Y
通讯作者：
Paterson,Y
通过单克隆抗体对病毒进行抗原表征。
影响因子：
10.5
作者：
Yewdell,JW;Gerhard,W
通讯作者：
Gerhard,W
氨基酸取代对溶菌酶活性位点区域的局部影响：物理和免疫学结果的比较。
影响因子：
2.9
作者：
Hornbeck,PV;Wilson,AC
通讯作者：
Wilson,AC