Slip-sliding away: serial changes and homoplasy in repeat number in the Drosophila yakuba homolog of human cancer susceptibility gene BRCA2.
Slip-sliding away: serial changes and homoplasy in repeat number in the Drosophila yakuba homolog of human cancer susceptibility gene BRCA2.
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DOI：
10.1371/journal.pone.0011006
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发表时间：
2010-06-08
期刊：
影响因子：
3.7
通讯作者：
Noor MA
中科院分区：
文献类型：
--
作者：
Bennett SM;Mercer JM;Noor MA
最近的几项研究检查了果蝇同源物的功能和进化人类乳腺癌易感基因BRCA2，命名为dmbrca2。我们以前确定了什么似乎是一个最近的扩展在RAD51结合BRC重复阵列的祖先果蝇yakuba。在这项研究中，我们研究的变化模式和进化的dmbrca2 BRC重复阵列内D。雅库巴及其近亲。我们开发了一个模型，不平等的交换可能产生了扩展的形式，但我们也观察到短的重复形式，典型的其他物种在D。melanogaster类群，在D. yakuba和D. santomea。这些短形式似乎并不完全相同的血统，这表明dmbrca 2在D。melanogaster亚群涉及重复单位收缩，导致同质形式。我们认为dmbrca2基因在D. yakuba和其他果蝇物种中的基因组序列可能比通过检查已发表的每个物种的单基因组序列所能推断的更为复杂。
Several recent studies have examined the function and evolution of a Drosophila homolog to the human breast cancer susceptibility gene BRCA2, named dmbrca2. We previously identified what appeared to be a recent expansion in the RAD51-binding BRC-repeat array in the ancestor of Drosophila yakuba. In this study, we examine patterns of variation and evolution of the dmbrca2 BRC-repeat array within D. yakuba and its close relatives. We develop a model of how unequal crossing over may have produced the expanded form, but we also observe short repeat forms, typical of other species in the D. melanogaster group, segregating within D. yakuba and D. santomea. These short forms do not appear to be identical-by-descent, suggesting that the history of dmbrca2 in the D. melanogaster subgroup has involved repeat unit contractions resulting in homoplasious forms. We conclude that the evolutionary history of dmbrca2 in D. yakuba and perhaps in other Drosophila species may be more complicated than can be inferred from examination of the published single genome sequences per species.
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