Artemisinin production in Artemisia annua: studies in planta and results of a novel delivery method for treating malaria and other neglected diseases.
Artemisinin production in Artemisia annua: studies in planta and results of a novel delivery method for treating malaria and other neglected diseases.
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DOI：
10.1007/s11101-010-9166-0
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发表时间：
2011-06
期刊：
影响因子：
--
通讯作者：
Reed DW
中科院分区：
文献类型：
--
作者：
Weathers PJ;Arsenault PR;Covello PS;McMickle A;Teoh KH;Reed DW
黄花蒿产生倍半萜内酯青蒿素，这是一种有效的抗疟疾药物，也可以有效地治疗其他寄生虫病、一些病毒感染和各种肿瘤。青蒿素也是一种化感除草剂，可以抑制其他植物的生长。不幸的是，这种化合物供不应求，因此，人们对其在工厂中的生产以及低成本的药物输送方法都很感兴趣。在这里，我们综述了我们最近关于青蒿素在植物发育过程中产生青蒿素的研究，因为它从营养生长阶段移动到生殖阶段(花芽和完全花形成)，对糖的响应，并与ROS，过氧化氢的产生相一致。我们还提供了动物实验的新数据，这些实验测量了直接使用干燥植物作为治疗药物的潜力。总而言之，这些结果提供了一个比以前更全面的青蒿素生物合成调控观点的概要。我们还建议采用另一种低成本的药物输送方法来治疗疟疾和其他被忽视的热带疾病。
Artemisia annua L. produces the sesquiterpene lactone, artemisinin, a potent antimalarial drug that is also effective in treating other parasitic diseases, some viral infections and various neoplasms. Artemisinin is also an allelopathic herbicide that can inhibit the growth of other plants. Unfortunately, the compound is in short supply and thus, studies on its production in the plant are of interest as are low cost methods for drug delivery. Here we review our recent studies on artemisinin production in A. annua during development of the plant as it moves from the vegetative to reproductive stage (flower budding and full flower formation), in response to sugars, and in concert with the production of the ROS, hydrogen peroxide. We also provide new data from animal experiments that measured the potential of using the dried plant directly as a therapeutic. Together these results provide a synopsis of a more global view of regulation of artemisinin biosynthesis in A. annua than previously available. We further suggest an alternative low cost method of drug delivery to treat malaria and other neglected tropical diseases.
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影响因子：
10.4
作者：
Fabricant, DS;Farnsworth, NR
通讯作者：
Farnsworth, NR
影响因子：
2.1
作者：
Brown, Geoffrey D.;Sy, Lai-King
通讯作者：
Sy, Lai-King
DOI：
10.1111/j.1749-6632.1983.tb47334.x
发表时间：
1983-01-01
影响因子：
5.2
作者：
KHARASCH, N;THYAGARAJAN, BS
通讯作者：
THYAGARAJAN, BS
影响因子：
6.9
作者：
Gollop, R;Even, S;Perl, A
通讯作者：
Perl, A
DOI：
10.1016/s0035-9203(96)90480-0
发表时间：
1996-01-01
影响因子：
2.2
作者：
Alin, MH;Ashton, M;Bjorkman, A
通讯作者：
Bjorkman, A