Repeated exposure to challenging environmental conditions influences telomere dynamics across adult life as predicted by changes in mortality risk
Repeated exposure to challenging environmental conditions influences telomere dynamics across adult life as predicted by changes in mortality risk
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正如死亡风险变化所预测的那样，反复暴露于具有挑战性的环境条件会影响整个成年生活中的端粒动态
DOI：
10.1096/fj.202100556r
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Monaghan, Pat
中科院分区：
文献类型：
--
作者：
Marasco, Valeria;Boner, Winnie;Griffiths, Kate;Heidinger, Britt;Monaghan, Pat
压力暴露的影响可能因生命阶段和压力源而异。虽然有人假设，轻度压力暴露可能有有益的影响，这种影响的持续时间和潜在的机制尚不清楚。虽然对早期生活压力的长期影响进行了相对较好的研究，但我们对成年后暴露的影响知之甚少，因为早期和成年生活环境通常相似。我们以前报道过，反复实验暴露于相对温和的应激源的雌性斑胸草雀，首次经历在年轻的成年期，最初没有影响死亡风险，降低死亡率在中年，但显然有益的影响消失在老年。我们在这里表明，这是由对照组和压力暴露组之间端粒变化模式的差异所支撑的，压力暴露的鸟类在成年中期表现出端粒丢失减少。因此，我们提供了新的实验证据，端粒动力学起着关键作用，连接压力弹性和衰老。
The effects of stress exposure are likely to vary depending on life‐stage and stressor. While it has been postulated that mild stress exposure may have beneficial effects, the duration of such effects and the underlying mechanisms are unclear. While the long‐term effects of early‐life stress are relatively well studied, we know much less about the effects of exposure in adulthood since the early‐ and adult‐life environments are often similar. We previously reported that repeated experimental exposure to a relatively mild stressor in female zebra finches, first experienced in young adulthood, initially had no effect on mortality risk, reduced mortality in middle age, but the apparently beneficial effects disappeared in old age. We show here that this is underpinned by differences between the control and stress‐exposed group in the pattern of telomere change, with stress‐exposed birds showing reduced telomere loss in middle adulthood. We thereby provide novel experimental evidence that telomere dynamics play a key role linking stress resilience and aging.
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