The Role of Resveratrol in Mammalian Reproduction.
The Role of Resveratrol in Mammalian Reproduction.
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DOI：
10.3390/molecules25194554
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发表时间：
2020-10-05
期刊：
影响因子：
--
通讯作者：
Maranesi M
中科院分区：
文献类型：
--
作者：
Pasquariello R;Verdile N;Brevini TAL;Gandolfi F;Boiti C;Zerani M;Maranesi M
白藜芦醇是研究最多的天然多酚化合物之一，存在于70多种植物和红酒中。这种多酚的广泛兴趣来自其抗氧化，抗炎和抗衰老特性。一些研究已经确定白藜芦醇调节动物繁殖。然而，其作用机制和潜在的治疗效果仍不清楚。本文旨在阐明白藜芦醇在雄性和雌性生殖功能中的作用，重点是兽医感兴趣的动物。在女性中，白藜芦醇被认为是一种植物雌激素，因为它能够通过sirtuins，特别是SIRT1调节卵巢功能和类固醇合成。白藜芦醇也被用于提高老化卵母细胞的质量，并作为配子冷冻保护剂，主要具有抗氧化和抗凋亡作用。在男性中，白藜芦醇通过激活AMPK途径增强睾丸功能和精子发生。此外，白藜芦醇已被补充到精液补充剂中，提高了精子质量的保存。总之，白藜芦醇具有改善卵巢和睾丸功能的潜在有益作用。
Resveratrol is one of the most investigated natural polyphenolic compounds and is contained in more than 70 types of plants and in red wine. The widespread interest in this polyphenol derives from its antioxidant, anti-inflammatory and anti-aging properties. Several studies have established that resveratrol regulates animal reproduction. However, the mechanisms of action and the potential therapeutic effects are still unclear. This review aims to clarify the role of resveratrol in male and female reproductive functions, with a focus on animals of veterinary interest. In females, resveratrol has been considered as a phytoestrogen due to its capacity to modulate ovarian function and steroidogenesis via sirtuins, SIRT1 in particular. Resveratrol has also been used to enhance aged oocyte quality and as a gametes cryo-protectant with mainly antioxidant and anti-apoptotic effects. In males, resveratrol enhances testes function and spermatogenesis through activation of the AMPK pathway. Furthermore, resveratrol has been supplemented to semen extenders, improving the preservation of sperm quality. In conclusion, resveratrol has potentially beneficial effects for ameliorating ovarian and testes function.
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影响因子：
2.2
作者：
Andersen, Anne Hoeg;Thinnesen, Mette;Goericke-Pesch, Sandra
通讯作者：
Goericke-Pesch, Sandra
影响因子：
3.2
作者：
Biasutto, Lucia;Mattarei, Andrea;Zoratti, Mario
通讯作者：
Zoratti, Mario
DOI：
10.1002/mrd.1120230108
发表时间：
1989-05-01
期刊：
GAMETE RESEARCH
影响因子：
--
作者：
ALVAREZ, JG;STOREY, BT
通讯作者：
STOREY, BT
影响因子：
2.9
作者：
Bunney PE;Zink AN;Holm AA;Billington CJ;Kotz CM
通讯作者：
Kotz CM
影响因子：
1.8
作者：
Atessahin, Ahmet;Bucak, Mustafa Numan;Kizil, Meltem
通讯作者：
Kizil, Meltem