Colostrum Therapy for Human Gastrointestinal Health and Disease.
Colostrum Therapy for Human Gastrointestinal Health and Disease.
复制标题
初乳治疗人类胃肠道健康和疾病。
DOI：
10.3390/nu13061956
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发表时间：
2021-06-07
期刊：
影响因子：
5.9
通讯作者：
Kelly P
中科院分区：
文献类型：
--
作者：
Chandwe K;Kelly P
越来越多的人认识到，广泛的胃肠道疾病和一些全身性疾病的特征在于粘膜屏障的失效。牛初乳是一种复杂的生物液体，富含生长因子、营养素、激素和旁分泌因子，具有一系列可能有助于各种感染、炎症和损伤条件下粘膜愈合的特性。在这篇综述中，我们描述了肠道屏障的解剖学和生理学，以及它是如何失败的。我们调查选定的疾病，其中障碍功能障碍有助于疾病的发病机制或进展，并审查证据或反对牛初乳的疗效管理。这些疾病包括非甾体抗炎药（NSAID）引起的肠病、炎症性肠病（IBD）、坏死性小肠结肠炎、感染性腹泻、肠衰竭和癌症治疗引起的损伤。在动物模型中，牛初乳有益于NSAID肠病、IBD和肠衰竭。在人体试验中，有大量证据表明牛初乳对炎症性肠病和感染性腹泻有效。鉴于使用牛初乳作为粘膜愈合促进剂的强大科学依据，需要进一步的工作来确定其在治疗中的作用。
There is increasing awareness that a broad range of gastrointestinal diseases, and some systemic diseases, are characterized by failure of the mucosal barrier. Bovine colostrum is a complex biological fluid replete with growth factors, nutrients, hormones, and paracrine factors which have a range of properties likely to contribute to mucosal healing in a wide range of infective, inflammatory, and injury conditions. In this review, we describe the anatomy and physiology of the intestinal barrier and how it may fail. We survey selected diseases in which disordered barrier function contributes to disease pathogenesis or progression, and review the evidence for or against efficacy of bovine colostrum in management. These disorders include enteropathy due to non-steroidal anti-inflammatory drugs (NSAIDs), inflammatory bowel disease (IBD), necrotizing enterocolitis, infectious diarrhea, intestinal failure, and damage due to cancer therapy. In animal models, bovine colostrum benefits NSAID enteropathy, IBD, and intestinal failure. In human trials, there is substantial evidence of efficacy of bovine colostrum in inflammatory bowel disease and in infectious diarrhea. Given the robust scientific rationale for using bovine colostrum as a promoter of mucosal healing, further work is needed to define its role in therapy.
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影响因子：
5.1
作者：
Asaro, Joseph A.;Khan, Zarak;Codipilly, Champa N.
通讯作者：
Codipilly, Champa N.
影响因子：
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通讯作者：
Fukui, Hiroshi
影响因子：
3.4
作者：
de Onis M;Branca F
通讯作者：
Branca F
影响因子：
2
作者：
Balachandran, Binesh;Dutta, Sourabh;Kumar, Praveen
通讯作者：
Kumar, Praveen
影响因子：
2.5
作者：
Blais, M.;Pouliot, Y.;Lessard, M.
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Lessard, M.