Brain-derived neurotrophic factor interacts with adult-born immature cells in the dentate gyrus during consolidation of overlapping memories.
Brain-derived neurotrophic factor interacts with adult-born immature cells in the dentate gyrus during consolidation of overlapping memories.
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DOI：
10.1002/hipo.22304
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发表时间：
2014-08
期刊：
影响因子：
3.5
通讯作者：
Bussey, Timothy J.
中科院分区：
文献类型：
--
作者：
Bekinschtein, Pedro;Kent, Brianne A.;Oomen, Charlotte A.;Clemenson, Gregory D.;Gage, Fred H.;Saksida, Lisa M.;Bussey, Timothy J.
成功的记忆不仅包括随着时间的推移记住信息，还包括保持记忆的清晰和不易混淆。使相似输入模式的表示彼此更加不同的计算过程被称为“模式分离”。尽管成人出生的未成熟神经元与这一记忆特征有关，但这些神经元及其相关分子在重叠记忆处理中的确切作用尚不清楚。最近，我们发现齿状回中的脑源性神经营养因子(BDNF)对重叠记忆的编码/巩固是必需的。在这项研究中，我们提供的证据表明，巩固这些“模式分离”的记忆需要脑源性神经营养因子对未成熟神经元的特殊作用。
Successful memory involves not only remembering information over time but also keeping memories distinct and less confusable. The computational process for making representations of similar input patterns more distinct from each other has been referred to as “pattern separation.” Although adult-born immature neurons have been implicated in this memory feature, the precise role of these neurons and associated molecules in the processing of overlapping memories is unknown. Recently, we found that brain-derived neurotrophic factor (BDNF) in the dentate gyrus is required for the encoding/consolidation of overlapping memories. In this study, we provide evidence that consolidation of these “pattern-separated” memories requires the action of BDNF on immature neurons specifically.
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影响因子：
5.3
作者：
Oomen, Charlotte A.;Soeters, Heleen;Krugers, Harm
通讯作者：
Krugers, Harm
DOI：
10.1523/jneurosci.1692-12.2012
发表时间：
2012-06-20
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Kheirbek MA;Tannenholz L;Hen R
通讯作者：
Hen R
影响因子：
3.5
作者：
Tronel, Sophie;Belnoue, Laure;Abrous, Djoher Nora
通讯作者：
Abrous, Djoher Nora
影响因子：
2
作者：
Jessberger, Sebastian;Clark, Robert E.;Gage, Fred H.
通讯作者：
Gage, Fred H.
影响因子：
3.3
作者：
Mou L;Heldt SA;Ressler KJ
通讯作者：
Ressler KJ