Sex differences in innate immunity and its impact on opioid pharmacology.
Sex differences in innate immunity and its impact on opioid pharmacology.
复制标题
DOI：
10.1002/jnr.23852
复制
发表时间：
2017-01-02
影响因子：
4.2
通讯作者：
Murphy, Anne Z.
中科院分区：
文献类型：
--
作者：
Doyle, Hillary H.;Murphy, Anne Z.
吗啡一直以来都是且至今仍是治疗疼痛最为强效且应用广泛的药物之一。针对疼痛与镇痛方面性别差异展开研究的临床及动物模型表明，吗啡对雄性的镇痛效果强于雌性。除了与神经元μ阿片受体结合外，吗啡还会与位于神经胶质细胞上的天然免疫受体——Toll样受体4（TLR4）相结合。神经胶质细胞TLR4的激活会引发一种神经炎症反应，而这种反应会直接对抗吗啡的镇痛作用。许多物种中，雌性的免疫系统比雄性更为活跃；然而，很少有研究将神经胶质细胞作为导致吗啡性别二态性反应的潜在机制来进行探究。这篇综述阐述了神经胶质细胞在吗啡镇痛性别差异所涉及的关键过程中的作用，并提出以神经胶质细胞为靶点或许能够改进当前的疼痛治疗策略。
Morphine has been and continues to be one of the most potent and widely used drugs for the treatment of pain. Clinical and animal models investigating sex differences in pain and analgesia demonstrate that morphine is a more potent analgesic in males than in females. In addition to binding to the neuronal mu opioid receptor, morphine binds to the innate immune receptor toll-like receptor 4 (TLR4), located on glial cells. Activation of glial TLR4 initiates a neuroinflammatory response that directly opposes morphine analgesia. Females of many species have a more active immune system than males; however, few studies have investigated glial cells as a potential mechanism driving sexually dimorphic responses to morphine. This review illustrates the involvement of glial cells in key processes underlying observed sex differences in morphine analgesia, and suggests that targeting glia may improve current treatment strategies for pain.
登录
查看更多内容
影响因子：
3.4
作者：
Comer, Sandra D.;Cooper, Ziva D.;Kowalczyk, William J.;Sullivan, Maria A.;Evans, Suzette M.;Bisaga, Adam M.;Vosburg, Suzanne K.
通讯作者：
Vosburg, Suzanne K.
大鼠口面部持续性疼痛模型外周 Mu-阿片受体介导镇痛的性别差异
影响因子：
3.7
作者：
Bai X;Zhang X;Li Y;Lu L;Li B;He X
通讯作者：
He X
影响因子：
4.4
作者：
Chilet-Rosell, E.;Ruiz-Cantero, M. T.;Horga, J. F.
通讯作者：
Horga, J. F.
影响因子：
5.1
作者：
Azuma, Y;Ohura, K
通讯作者：
Ohura, K
影响因子：
6.2
作者：
Bidlack, Jean M.;Khimich, Maxim;Tipton, Christopher M.
通讯作者：
Tipton, Christopher M.