Evaluation of potential sex differences in the subjective and analgesic effects of morphine in normal, healthy volunteers.
Evaluation of potential sex differences in the subjective and analgesic effects of morphine in normal, healthy volunteers.
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DOI：
10.1007/s00213-009-1703-4
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发表时间：
2010-01
影响因子：
3.4
通讯作者：
Vosburg, Suzanne K.
中科院分区：
文献类型：
--
作者：
Comer, Sandra D.;Cooper, Ziva D.;Kowalczyk, William J.;Sullivan, Maria A.;Evans, Suzette M.;Bisaga, Adam M.;Vosburg, Suzanne K.
在啮齿类动物中广泛记录了μ-阿片受体激动剂镇痛作用的性别差异，在非人灵长类动物中也有少量记录。到目前为止，很少有实验研究调查这种影响在人类身上，结论一直模棱两可。本研究的目的是探讨潜在的性别差异的镇痛，主观，性能和生理作用的吗啡在人类研究志愿者。使用双盲门诊程序，本研究调查了肌内吗啡（0、5和10 mg/70 kg，i.m.）男性（N=8）和女性（N=10）。主要的依赖性措施是镇痛，通过冷加压和机械压力测试进行评估。次级依赖性指标包括吗啡的主观、表现和生理作用，以及吗啡的血浆水平。吗啡的镇痛和性能效果在男性和女性之间没有差异，但在吗啡的主观效果上存在显着差异，特别是，男性报告了更大的积极影响，而女性报告了更大的负面影响后，吗啡给药。这些数据表明，在人类中，吗啡的主观情绪改变作用存在性别差异，但基于这一有限的样本，几乎没有证据表明其镇痛作用存在性别差异。
Sex differences in the analgesic effects of mu-opioid agonists have been documented extensively in rodents and, to a lesser extent, in non-human primates. To date, there have been few experimental studies investigating this effect in humans, and the conclusions have been equivocal. The aims of the present study were to examine potential sex differences in the analgesic, subjective, performance, and physiological effects of morphine in human research volunteers. Using a double-blind outpatient procedure, the present study investigated the effects of intramuscular morphine (0, 5, and 10 mg/70 kg, i.m.) in men (N=8) and women (N=10). The primary dependent measure was analgesia, as assessed by the cold-pressor and mechanical-pressure tests. Secondary dependent measures included subjective, performance, and physiological effects of morphine, as well as plasma levels of morphine. No differences in the analgesic and performance effects of morphine were observed between men and women, but significant differences in morphine’s subjective effects were found. Specifically, men reported greater positive effects whereas women reported greater negative effects after morphine administration. These data suggest that in humans, there are sex differences in the subjective mood altering effects of morphine but, based on this limited sample, there is little evidence for sex differences in its analgesic effects.
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影响因子：
4
作者：
Fillingim, RB;Ness, TJ;Staud, R
通讯作者：
Staud, R
影响因子：
7.4
作者：
Dixon, KE;Thorn, BE;Ward, LC
通讯作者：
Ward, LC
影响因子：
7.6
作者：
Evans, SM;Haney, M;Foltin, RW
通讯作者：
Foltin, RW
DOI：
10.1080/14622299050011441
发表时间：
1999-12-01
期刊：
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
影响因子：
--
作者：
Eissenberg, T;Adams, C;Likness, M
通讯作者：
Likness, M
影响因子：
6
作者：
Darke, S;Sims, J;Wickes, W
通讯作者：
Wickes, W