3D maps localize caudate nucleus atrophy in 400 Alzheimer's disease, mild cognitive impairment, and healthy elderly subjects.
3D maps localize caudate nucleus atrophy in 400 Alzheimer's disease, mild cognitive impairment, and healthy elderly subjects.
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DOI：
10.1016/j.neurobiolaging.2010.05.002
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发表时间：
2010-08
影响因子：
4.2
通讯作者：
Alzheimer's Disease Neuroimaging Initiative
中科院分区：
文献类型：
--
作者：
Madsen SK;Ho AJ;Hua X;Saharan PS;Toga AW;Jack CR Jr;Weiner MW;Thompson PM;Alzheimer's Disease Neuroimaging Initiative
检查阿尔茨海默病（AD）中结构性脑萎缩的MRI研究通常集中在内侧颞叶和皮质结构上，但淀粉样蛋白和tau沉积物也在尾状核中积累。在这里，我们使用表面映射方法绘制了AD和轻度认知障碍（MCI）受试者的尾状核萎缩的3D轮廓，以确定潜在的临床和病理相关性。从400个基线MRI扫描（100个AD，200个MCI，100个健康老年人）中自动提取尾状核的3D表面模型。与对照组相比，MCI（左侧2.64%，右侧4.43%）和AD（左侧4.74%，右侧8.47%）的尾状核体积较低。尾状核萎缩与年龄、盒子总和和总体临床痴呆评分、延迟逻辑记忆评分、1年后MMSE下降和体重指数相关。右侧（而非左侧）体积减少与MCI向AD转化和CSF tau水平相关。正常的尾状核不对称性（右尾状核比左尾状核大3.9%）在AD中消失，表明优先出现右尾状核萎缩。自动尾状核地图可以补充其他MRI衍生的AD疾病负担的措施。
MRI research examining structural brain atrophy in Alzheimer's disease (AD) generally focuses on medial temporal and cortical structures, but amyloid and tau deposits also accumulate in the caudate. Here we mapped the 3D profile of caudate atrophy using a surface mapping approach in subjects with AD and mild cognitive impairment (MCI) to identify potential clinical and pathological correlates. 3D surface models of the caudate were automatically extracted from 400 baseline MRI scans (100 AD, 200 MCI, 100 healthy elderly). Compared to controls, caudate volumes were lower in MCI (2.64% left, 4.43% right) and AD (4.74% left, 8.47% right). Caudate atrophy was associated with age, sum-of-boxes and global Clinical Dementia Ratings, Delayed Logical Memory scores, MMSE decline 1 year later, and body mass index. Reduced right (but not left) volume was associated with MCI-to-AD conversion, and CSF tau levels. Normal caudate asymmetry (with the right 3.9% larger than left) was lost in AD, suggesting preferential right caudate atrophy. Automated caudate maps may complement other MRI-derived measures of disease burden in AD.
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通讯作者：
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