Age of First Overweight and Obesity, COVID-19 and Long COVID in Two British Birth Cohorts.
Age of First Overweight and Obesity, COVID-19 and Long COVID in Two British Birth Cohorts.
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DOI：
10.1007/s44197-023-00093-5
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发表时间：
2023-03
影响因子：
7.3
通讯作者：
Silverwood, Richard J.
中科院分区：
文献类型：
--
作者：
Staatz, Charis Bridger;Bann, David;Ploubidis, George B.;Goodman, Alissa;Silverwood, Richard J.
长时间暴露于肥胖，从而长时间处于炎症状态，可能会增加感染性疾病的易感性并使严重程度恶化。先前的横断面研究发现，较高的BMI与更糟糕的COVID-19结果有关，但对成年期BMI的相关性知之甚少。为了验证这一点，我们使用了1958年国家儿童发展研究（NCDS）和1970年英国队列研究（BCS 70）中收集的成年期体重指数（BMI）。参与者按他们首次超重（> 25 kg/m2）和肥胖（> 30 kg/m2）的年龄分组。Logistic回归用于评估与COVID-19（自我报告和血清学证实），严重程度（住院和与卫生服务接触）以及62岁（NCDS）和50岁（BCS 70）报告的长期COVID的相关性。与从未肥胖或超重的人相比，肥胖和超重的年龄较早与COVID-19不良结果的几率增加有关，但结果好坏参半，而且往往不够有力。那些早期暴露于肥胖的人在NCDS中患长期COVID的可能性是两倍多（比值比（OR）2.15，95%置信区间（CI）1.17-4.00），在BCS 70中是三倍（OR 3.01，95% CI 1.74-5.22）。在NCDS中，他们入院的可能性也超过4倍（OR 4.69，95% CI 1.64-13.39）。大多数相关性在某种程度上可以用同期BMI或报告的健康状况、糖尿病或高血压来解释;然而，与NCDS住院的相关性仍然存在。肥胖发病年龄较早与晚年的COVID-19结果有关，这为BMI升高对中年传染病结果的长期影响提供了证据。在线版本包含补充材料，可通过10.1007/s44197-023-00093-5获得。
Longer exposure to obesity, and thus a longer period in an inflamed state, may increase susceptibility to infectious diseases and worsen severity. Previous cross-sectional work finds higher BMI is related to worse COVID-19 outcomes, but less is known about associations with BMI across adulthood. To examine this, we used body mass index (BMI) collected through adulthood in the 1958 National Child Development Study (NCDS) and the 1970 British Cohort Study (BCS70). Participants were grouped by the age they were first overweight (> 25 kg/m2) and obese (> 30 kg/m2). Logistic regression was used to assess associations with COVID-19 (self-reported and serology-confirmed), severity (hospital admission and contact with health services) and long-COVID reported at ages 62 (NCDS) and 50 (BCS70). An earlier age of obesity and overweight, compared to those who never became obese or overweight, was associated with increased odds of adverse COVID-19 outcomes, but results were mixed and often underpowered. Those with early exposure to obesity were over twice as likely in NCDS (odds ratio (OR) 2.15, 95% confidence interval (CI) 1.17–4.00) and three times as likely in BCS70 (OR 3.01, 95% CI 1.74–5.22) to have long COVID. In NCDS they were also over four times as likely to be admitted to hospital (OR 4.69, 95% CI 1.64–13.39). Most associations were somewhat explained by contemporaneous BMI or reported health, diabetes or hypertension; however, the association with hospital admission in NCDS remained. An earlier age of obesity onset is related to COVID-19 outcomes in later life, providing evidence of the long-term impact of raised BMI on infectious disease outcomes in midlife. The online version contains supplementary material available at 10.1007/s44197-023-00093-5.
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影响因子：
4.8
作者：
Khanijahani A;Iezadi S;Gholipour K;Azami-Aghdash S;Naghibi D
通讯作者：
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影响因子：
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作者：
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DOI：
10.1016/s2213-8587(21)00089-9
发表时间：
2021-06
期刊：
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影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
Liang, Yajun
DOI：
10.5114/aoms.2016.58928
发表时间：
2017-06
期刊：
Archives of medical science : AMS
影响因子：
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作者：
Ellulu MS;Patimah I;Khaza'ai H;Rahmat A;Abed Y
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