Obesity and inflammation: the linking mechanism and the complications.
Obesity and inflammation: the linking mechanism and the complications.
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DOI：
10.5114/aoms.2016.58928
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发表时间：
2017-06
期刊：
影响因子：
--
通讯作者：
Abed Y
中科院分区：
文献类型：
--
作者：
Ellulu MS;Patimah I;Khaza'ai H;Rahmat A;Abed Y
肥胖是指异常或过多的脂肪堆积，可能会干扰保持最佳健康状态。脂肪组织中过多的常量营养素刺激它们释放炎症介质，如肿瘤坏死因子α和白介素6，并减少脂联素的产生，使其易于处于促炎状态和氧化应激状态。白介素6水平的升高刺激肝脏合成和分泌C反应蛋白。炎症作为一种危险因素，是凝血、动脉粥样硬化、代谢综合征、胰岛素抵抗和糖尿病等心血管疾病发生的内在机制。它还与非心血管疾病的发展有关，如牛皮癣、抑郁症、癌症和肾脏疾病。另一方面，脂联素水平降低是心血管死亡的重要预测因素，与空腹血糖受损有关，从而导致2型糖尿病、代谢异常、冠状动脉钙化和中风。最后，控制肥胖可以通过抑制炎症机制来帮助降低心血管疾病的风险和不良结局。
Obesity is the accumulation of abnormal or excessive fat that may interfere with the maintenance of an optimal state of health. The excess of macronutrients in the adipose tissues stimulates them to release inflammatory mediators such as tumor necrosis factor α and interleukin 6, and reduces production of adiponectin, predisposing to a pro-inflammatory state and oxidative stress. The increased level of interleukin 6 stimulates the liver to synthesize and secrete C-reactive protein. As a risk factor, inflammation is an imbedded mechanism of developed cardiovascular diseases including coagulation, atherosclerosis, metabolic syndrome, insulin resistance, and diabetes mellitus. It is also associated with development of non-cardiovascular diseases such as psoriasis, depression, cancer, and renal diseases. On the other hand, a reduced level of adiponectin, a significant predictor of cardiovascular mortality, is associated with impaired fasting glucose, leading to type-2 diabetes development, metabolic abnormalities, coronary artery calcification, and stroke. Finally, managing obesity can help reduce the risks of cardiovascular diseases and poor outcome via inhibiting inflammatory mechanisms.
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DOI：
10.1073/pnas.171320598
发表时间：
2001-08-14
影响因子：
11.1
作者：
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影响因子：
4.6
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影响因子：
5.8
作者：
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