Frontal theta is a signature of successful working memory manipulation.

Frontal theta is a signature of successful working memory manipulation.
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DOI:
10.1007/s00221-012-3305-3
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发表时间:
2013-01
影响因子:
2
通讯作者:
Aron, Adam R.
Aron, Adam R.
中科院分区:
医学4区
文献类型:
--
作者:
Itthipuripat, Sirawaj;Wessel, Jan R.;Aron, Adam R.

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工作记忆(WM)的更新/操纵是通过额基底神经节回路完成的。其中一种方法是通过神经振荡的同步。测试这一假设的第一步是清楚地建立一个额叶头皮脑电图签名的WM操作。虽然许多EEG研究确实揭示了WM的额叶EEG特征,特别是在θ频段(3-8 Hz),但很少有研究要求受试者操纵WM,而且在那些研究中,没有一个将EEG特征与操纵过程本身联系起来。在这里,我们采用了一个WM操作任务,已被证明与成像从事前额叶皮层和纹状体。我们调整了这项任务,以滴定WM操作的成功率约为50%。使用时频分析的EEG,我们表明,θ功率增加超过额叶皮层成功与失败的WM操作,特别是在操作事件的时间。这建立了WM操纵的明确EEG特征。未来的研究可以利用这一点来测试WM更新/操纵的额基底神经节假说。
It has been proposed that working memory (WM) is updated/manipulated via a fronto-basal-ganglia circuit. One way that this could happen is via the synchronization of neural oscillations. A first step towards testing this hypothesis is to clearly establish a frontal scalp EEG signature of WM manipulation. Although many EEG studies have indeed revealed frontal EEG signatures for WM, especially in the theta frequency band (3–8 Hz), few of them required subjects to manipulate WM, and of those that did, none specifically tied the EEG signature to the manipulation process per se. Here we employed a WM manipulation task that has been shown with imaging to engage the prefrontal cortex and the striatum. We adapted this task to titrate the success of WM manipulation to approximately 50%. Using time-frequency analysis of EEG, we showed that theta power is increased over frontal cortex for successful versus failed WM manipulation, specifically at the time of the manipulation event. This establishes a clear-cut EEG signature of WM manipulation. Future studies could employ this to test the fronto-basal-ganglia hypothesis of WM updating/manipulation.
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