Development of Elemental Technologies for Magnetic Hyperthermia in Cancer Treatment
Development of Elemental Technologies for Magnetic Hyperthermia in Cancer Treatment
复制标题
癌症治疗磁热疗基础技术的发展
DOI：
10.1007/978-3-030-66169-4_33
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Yamamoto Yoshiyuki
中科院分区：
文献类型：
--
作者：
Tonthat Loi;Aki Fumitaka;Mitobe Kazutaka;Yabukami Shin;Yamamoto Yoshiyuki
近年来，利用磁性粒子的热疗作为一种可能的癌症治疗方法已被广泛研究。该方法利用磁性颗粒注入肿瘤区域并受到外部高频磁场的作用，利用其产生的热量来诱导细胞凋亡（细胞死亡）。在之前的研究中，我们成功开发了居里温度约为40-45°C的微米级热敏铁磁颗粒作为自控加热元件，可以防止健康组织周围的局部过热。此外，利用其在居里温度附近磁导率的变化导致肿瘤区域周围磁通密度的变化，我们还开发了无线温度测量。此外，为了定位从体表看不到的磁性粒子，我们还开发了一种自动定位系统，该系统使用配备有对称安装在加热线圈中的三个检测线圈的机械臂。为了使我们提出的基本技术在临床环境中可行，我们还开发了一种磁热疗系统，可以治疗深达 5 厘米的深部肿瘤。在本文中，我们报告了迄今为止已开发的基本技术，例如加热元件、温度和位置监控技术。
Hyperthermia utilizing magnetic particles has been widely studied as a possible method for cancer treatment in recent years. This method induces apoptosis (cell death) using heat generation from magnetic particles which are injected into a tumor region and subjected to an external high-frequency magnetic field. In previous studies, we succeeded in developing microsize thermosensitive ferromagnetic particles with a low Curie temperature of around 40–45 °C as a self-controlled heating element that possibly prevents the local overheating surrounding healthy tissues. Further, by utilizing the change of its permeability around its Curie temperature resulting in the change in the magnetic flux density around tumor region, we also developed a wireless temperature measurement. In addition, to localize magnetic particles which cannot be seen from the body surface, we also developed an automatic localization system by using a robot arm equipped with three detection coils symmetrically installed in heating coil. To make our proposed elemental technologies feasible in clinical settings, we have also been developing a magnetic hyperthermia system that can treat deep-seated tumors up to 5 cm. In this paper, we report our elemental technologies which have been developed so far such as heating elements, temperature and position monitoring technologies.
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DOI：
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发表时间：
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期刊：
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DOI：
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发表时间：
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期刊：
--
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影响因子：
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作者：
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DOI：
10.1201/b12983
发表时间：
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期刊：
Journal of Infrared, Millimeter, and Terahertz Waves
影响因子：
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作者：
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