Regional cerebral glucose utilization in chronic organic mental disorders associated with alcoholism.

Regional cerebral glucose utilization in chronic organic mental disorders associated with alcoholism.
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与酒精中毒相关的慢性器质性精神障碍中的局部脑葡萄糖利用。

DOI:
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发表时间:
1992
期刊:
The Journal of Neuropsychiatry and Clinical Neurosciences
影响因子:
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通讯作者:
Michael J. Eckardt
Michael J. Eckardt
中科院分区:
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文献类型:
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作者:
Peter R. Martin;D. Rio;Bryon Adinoff;J. Johnson;J. Bisserbe;R. Rawlings;J. Rohrbaugh;J. M. Stapleton;Michael J. Eckardt

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使用[18 F]2-氟-2-脱氧葡萄糖正电子发射断层扫描技术,测定了10例酒精性器质性精神障碍脱毒患者和7例年龄相当的正常志愿者的局部脑葡萄糖利用率(CMRglu)。尽管灰质和白色质CMRglu没有显着差异,但酒精患者左侧小脑和顶叶皮质区的标准化CMRglu增加,而右侧后白色质和前颞区的CMRglu减少,并且局部CMRglu的模式在两组之间存在差异。结果表明,酒精性慢性器质性精神障碍的右侧和额叶脑区的功能中断和小脑皮质连接的过度活跃。
Localized cerebral utilization rates for glucose (CMRglu) were determined in 10 detoxified patients with alcoholic organic mental disorders and in 7 age-equivalent normal volunteers using [18F]2-fluoro-2-deoxyglucose positron emission tomography. Although gray and white matter CMRglu were not significantly different, normalized CMRglu was increased in the left cerebellar and parietal cortical regions and decreased in the right posterior white matter and anterior temporal regions of alcoholic patients, and the pattern of regional CMRglu differed between the two groups. The results suggest functional disruption of right-sided and frontal brain regions and hyperactivity of cerebellar-cortical connections in alcoholic chronic organic mental disorders.
非科尔萨科夫慢性酒精中毒患者局部脑葡萄糖代谢率的改变。
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发表时间: 1987
影响因子: --
作者:
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影响因子: --
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