Antidiabetic Drugs Can Reduce the Harmful Impact of Chronic Smoking on Post-Traumatic Brain Injuries.
Antidiabetic Drugs Can Reduce the Harmful Impact of Chronic Smoking on Post-Traumatic Brain Injuries.
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DOI：
10.3390/ijms24076219
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发表时间：
2023-03-25
影响因子：
5.6
通讯作者：
Cucullo, Luca
中科院分区：
文献类型：
--
作者：
Sivandzade, Farzane;Alqahtani, Faleh;Dhaibar, Hemangini;Cruz-Topete, Diana;Cucullo, Luca
创伤性脑损伤是世界范围内脑血管和神经疾病的主要原因。目前的科学研究人员认为，疾病前的条件，如吸烟(TS)可以加剧脑损伤后的脑损伤，并对康复造成负面影响。这与TS释放的活性氧(ROS)、尼古丁和氧化应激(OS)刺激影响血脑屏障(BBB)内皮细胞所致的血管内皮功能障碍有关。有趣的是，这些BBB损伤的致病调节因子类似于与高血糖相关的那些。二甲双胍(MF)和罗格列酮(RSG)等抗糖尿病药物被证明可以预防/减少慢性TS暴露促进的BBB损害。因此，采用活体方法，我们评估了颅脑损伤后使用MF或RSG治疗以减少脑损伤后血脑屏障损伤和脑损伤的TS增强的有效性。为此，我们采用了一种体内减重创伤性脑损伤模型，使用的是雄性C57BL/6J小鼠，这些小鼠长期暴露于TS中，并分别接受了MF或RSG的创伤后治疗。我们的结果显示，这些抗糖尿病药物可以对抗TS促进的核因子红系相关因子2(NRF2)表达的下调，并伴随着抑制TS增强的OS、炎症和脑损伤后BBB完整性的丧失。综上所述，我们的研究结果表明，MF和RSG可以减少慢性吸烟对创伤后脑损伤的有害影响。
Traumatic Brain Injury (TBI) is a primary cause of cerebrovascular and neurological disorders worldwide. The current scientific researchers believe that premorbid conditions such as tobacco smoking (TS) can exacerbate post-TBI brain injury and negatively affect recovery. This is related to vascular endothelial dysfunction resulting from the exposure to TS-released reactive oxygen species (ROS), nicotine, and oxidative stress (OS) stimuli impacting the blood–brain barrier (BBB) endothelium. Interestingly, these pathogenic modulators of BBB impairment are similar to those associated with hyperglycemia. Antidiabetic drugs such as metformin (MF) and rosiglitazone (RSG) were shown to prevent/reduce BBB damage promoted by chronic TS exposure. Thus, using in vivo approaches, we evaluated the effectiveness of post-TBI treatment with MF or RSG to reduce the TS-enhancement of BBB damage and brain injury after TBI. For this purpose, we employed an in vivo weight-drop TBI model using male C57BL/6J mice chronically exposed to TS with and without post-traumatic treatment with MF or RSG. Our results revealed that these antidiabetic drugs counteracted TS-promoted downregulation of nuclear factor erythroid 2-related factor 2 (NRF2) expression and concomitantly dampened TS-enhanced OS, inflammation, and loss of BBB integrity following TBI. In conclusion, our findings suggest that MF and RSG could reduce the harmful impact of chronic smoking on post-traumatic brain injuries.
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影响因子：
3.3
作者：
Galgano M;Toshkezi G;Qiu X;Russell T;Chin L;Zhao LR
通讯作者：
Zhao LR
DOI：
10.1042/cs20160043
发表时间：
2016-07-01
期刊：
Clinical science (London, England : 1979)
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