The impact of heat exposures on biomarkers of AKI and plasma metabolome among agricultural and non-agricultural workers.
The impact of heat exposures on biomarkers of AKI and plasma metabolome among agricultural and non-agricultural workers.
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DOI：
10.1016/j.envint.2023.108206
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发表时间：
2023-10
影响因子：
11.8
通讯作者：
Liang, Donghai
中科院分区：
文献类型：
--
作者：
Chicas, Roxana C.;Wang, Yilin;Weil, E. Jennifer;Elon, Lisa;Xiuhtecutli, Nezahualcoyotl;Houser, Madelyn C.;Jones, Dean P.;Sands, Jeff M.;Hertzberg, Vicki;Mccauley, Linda;Liang, Donghai
农业工人持续暴露于高温环境中，容易发生急性肾损伤。农业工人阿基的潜在病理生理学和详细的分子机制，以及HRI和热应激暴露的不成比例的负担还没有得到很好的理解，特别是在细胞代谢水平。本研究的目的是通过农业和非农业工人的非靶向高分辨率代谢组学研究热暴露对肾脏生物标志物和人体代谢组的影响。对63名农业工人和27名非农业工人在轮班前和轮班后进行血、尿标本采集。我们评估了轮班前和轮班后的肾脏生物标志物，并使用高分辨率质谱和液相色谱法完成了非靶向代谢组学。全代谢组关联研究（MWAS）模型确定了农业工人和非农业工人之间差异表达的代谢特征。轮班前肌酐和骨桥蛋白的中位数农业工人高于非农业工人（p < 0.05）。代谢途径富集分析显示，农业工人和非农业工人之间存在27种不同的途径（p < 0.05），包括TCA循环和尿素循环、碳水化合物代谢、组氨酸代谢和改变的微生物组莽草酸途径的证据。这是第一次调查的代谢途径，受影响的农业工人谁是暴露于热相比，非热暴露的工人。这项研究显示了中央代谢系统对影响人类健康的热暴露的广泛反应。
Agricultural workers are consistently exposed to elevated heat exposures and vulnerable to acute kidney injury. The underlying pathophysiology and detailed molecular mechanisms of AKI among agricultural workers, and the disproportionate burden of HRI and heat stress exposure are not well understood, especially at the level of cellular metabolism. The aim of this study was to examine the impact of heat exposures on renal biomarkers and on the human metabolome via untargeted high-resolution metabolomics among agricultural and non-agricultural workers. Blood and urine samples were collected pre- and post-work shift from 63 agricultural workers and 27 non– agricultural workers. We evaluated pre- and post-work shift renal biomarkers and completed untargeted metabolomics using high-resolution mass spectrometry with liquid chromatography. Metabolome-wide association studies (MWAS) models identified the metabolic features differentially expressed between agricultural workers and non-agricultural workers. Median values of pre-shift creatinine and osteopontin (p < 0.05) were higher for agricultural workers than non-agricultural workers. Metabolic pathway enrichment analyses revealed 27 diverse pathways differed between agricultural workers and non-agricultural workers (p < 0.05) including TCA cycle and urea cycle, carbohydrate metabolism, histidine metabolism and evidence for altered microbiome shikimate pathway. This is the first investigation on the metabolic pathways that are affected among agricultural workers who are exposed to heat compared to non-heat exposed workers. This study shows extensive responses of central metabolic systems to heat exposures that impact human health.
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DOI：
10.1186/cc11454
发表时间：
2013-02-04
期刊：
Critical care (London, England)
影响因子：
--
作者：
Kellum JA;Lameire N;KDIGO AKI Guideline Work Group
通讯作者：
KDIGO AKI Guideline Work Group
DOI：
10.3390/ijerph17113775
发表时间：
2020-06-01
影响因子：
--
作者：
Al-Bouwarthan, Mohammed;Quinn, Margaret M.;Wegman, David H.
通讯作者：
Wegman, David H.
影响因子：
6.1
作者：
Legouis, David;Faivre, Anna;de Seigneux, Sophie
通讯作者：
de Seigneux, Sophie
DOI：
10.2215/cjn.13841215
发表时间：
2016-08-01
影响因子：
9.8
作者：
Glaser, Jason;Lemery, Jay;Johnson, Richard J.
通讯作者：
Johnson, Richard J.
影响因子：
8
作者：
Fucile, Geoffrey;Garcia, Christel;Christendat, Dinesh
通讯作者：
Christendat, Dinesh