Correspondence of functional connectivity gradients across human isocortex, cerebellum, and hippocampus.

Correspondence of functional connectivity gradients across human isocortex, cerebellum, and hippocampus.
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DOI:
10.1038/s42003-023-04796-0
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发表时间:
2023-04-12
影响因子:
5.9
通讯作者:
Barrett, Lisa Feldman
Barrett, Lisa Feldman
中科院分区:
生物学2区
文献类型:
--
作者:
Katsumi, Yuta;Zhang, Jiahe;Chen, Danlei;Kamona, Nada;Bunce, Jamie G.;Hutchinson, J. Benjamin;Yarossi, Mathew;Tunik, Eugene;Dickerson, Bradford C.;Quigley, Karen S.;Barrett, Lisa Feldman

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梯度映射是一种将高维生物学特征概括为低维流形表征的重要技术,可用于探索大脑皮层不同层次的结构-功能关系。虽然最近的研究利用这种技术描述了几种大脑结构中功能连接的主要梯度,但很少有研究在一个共同的系统级框架下系统地检查了这种跨结构梯度的对应关系。通过静息状态功能磁共振成像,我们发现同皮层的组织原理,以及小脑和海马相对于同皮层的组织原理,可以用两个常见的功能梯度来描述。我们认为,这些结构之间功能连接梯度的相似性可以在基于预测处理原理的通用计算框架内进行有意义的解释。目前的结果,以及他们提出的具体假设,代表了迈向大脑功能综合解释的重要一步。对来自人类连接组计划和脑基因组学上层结构计划的功能性MRI数据的分析揭示了人类同皮质、小脑和海马体之间共同的功能梯度。
Gradient mapping is an important technique to summarize high dimensional biological features as low dimensional manifold representations in exploring brain structure-function relationships at various levels of the cerebral cortex. While recent studies have characterized the major gradients of functional connectivity in several brain structures using this technique, very few have systematically examined the correspondence of such gradients across structures under a common systems-level framework. Using resting-state functional magnetic resonance imaging, here we show that the organizing principles of the isocortex, and those of the cerebellum and hippocampus in relation to the isocortex, can be described using two common functional gradients. We suggest that the similarity in functional connectivity gradients across these structures can be meaningfully interpreted within a common computational framework based on the principles of predictive processing. The present results, and the specific hypotheses that they suggest, represent an important step toward an integrative account of brain function. Analysis of functional MRI data from the Human Connectome Project and Brain Genomics Superstruct Project reveals common functional gradients among the human isocortex, cerebellum, and hippocampus.
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