Sensory-related neural activity regulates the structure of vascular networks in the cerebral cortex.
Sensory-related neural activity regulates the structure of vascular networks in the cerebral cortex.
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DOI：
10.1016/j.neuron.2014.07.034
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发表时间：
2014-09-03
期刊：
影响因子：
16.2
通讯作者：
Gu C
中科院分区：
文献类型：
--
作者：
Lacoste B;Comin CH;Ben-Zvi A;Kaeser PS;Xu X;Costa Lda F;Gu C
神经血管的相互作用对于正常的大脑功能是必不可少的。虽然神经活动对脑血流量的影响已经被广泛研究，但神经活动是否影响血管模式仍然难以捉摸。在这里，我们证明了神经活动促进了出生后早期小鼠桶状皮质血管网络的形成。利用遗传学、成像和计算工具的组合来同时分析神经元和血管成分，我们发现，当感觉输入减少时，桶状皮质中的血管密度和分支减少，要么是完全去传入，要么是丘脑皮质突触神经递质释放的遗传障碍，要么是通过拔胡须选择性地减少与感觉相关的神经活动。相反，通过胡须刺激增强神经活动会导致血管密度和分支的增加。神经活动是触发血管网络改变的必要条件和充分条件，这一发现揭示了神经血管相互作用的一个新特征。
Neurovascular interactions are essential for proper brain function. While the effect of neural activity on cerebral blood flow has been extensively studied, whether neural activity influences vascular patterning remains elusive. Here, we demonstrate that neural activity promotes the formation of vascular networks in the early postnatal mouse barrel cortex. Using a combination of genetics, imaging, and computational tools to allow simultaneous analysis of neuronal and vascular components, we found that vascular density and branching were decreased in the barrel cortex when sensory input was reduced by either a complete deafferentation, a genetic impairment of neurotransmitter release at thalamocortical synapses, or a selective reduction of sensory-related neural activity by whisker plucking. In contrast, enhancement of neural activity by whisker stimulation led to an increase in vascular density and branching. The finding that neural activity is necessary and sufficient to trigger alterations of vascular networks reveals a novel feature of neurovascular interactions.
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