Sepsis-induced AKI: From pathogenesis to therapeutic approaches.
Sepsis-induced AKI: From pathogenesis to therapeutic approaches.
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DOI：
10.3389/fphar.2022.981578
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发表时间：
2022
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
脓毒症是由感染性或非感染性因素引起的一种异质性、高度复杂的临床综合征。急性肾损伤（acute kidney injury，阿基）是脓毒症最常见、最严重的并发症之一，死亡率高，预后差。最近的证据已经确定自噬参与脓毒症相关阿基的病理生理学。尽管使用抗生素，败血症患者的死亡率仍然处于极高水平。除了传统的治疗方法外，许多天然产物，包括植物化学物质及其衍生物，已被证明通过多种机制发挥保护作用，如调节自噬，抑制炎症，纤维化和凋亡等。越来越多的证据也表明，许多药物抑制剂可能对脓毒症诱导的阿基具有潜在的治疗作用。因此，了解脓毒症诱导的阿基的病理生理学可能有助于开发新的治疗方法来减轻脓毒症的并发症并降低死亡率。本文综述了脓毒症相关阿基病理生理机制的最新进展，特别关注自噬，并总结了植物化学物质和药理学抑制剂的潜在治疗作用。
Sepsis is a heterogenous and highly complex clinical syndrome, which is caused by infectious or noninfectious factors. Acute kidney injury (AKI) is one of the most common and severe complication of sepsis, and it is associated with high mortality and poor outcomes. Recent evidence has identified that autophagy participates in the pathophysiology of sepsis-associated AKI. Despite the use of antibiotics, the mortality rate is still at an extremely high level in patients with sepsis. Besides traditional treatments, many natural products, including phytochemicals and their derivatives, are proved to exert protective effects through multiple mechanisms, such as regulation of autophagy, inhibition of inflammation, fibrosis, and apoptosis, etc. Accumulating evidence has also shown that many pharmacological inhibitors might have potential therapeutic effects in sepsis-induced AKI. Hence, understanding the pathophysiology of sepsis-induced AKI may help to develop novel therapeutics to attenuate the complications of sepsis and lower the mortality rate. This review updates the recent progress of underlying pathophysiological mechanisms of sepsis-associated AKI, focuses specifically on autophagy, and summarizes the potential therapeutic effects of phytochemicals and pharmacological inhibitors.
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影响因子：
4.6
作者：
Asseri SM;Elsherbiny NM;El-Sherbiny M;Sherif IO;Alsamman AM;Maysarah NM;Elsherbini AM
通讯作者：
Elsherbini AM
影响因子：
5.6
作者：
Bai, Xiaoxue;Zhu, Yingjie;Luo, Jingjing
通讯作者：
Luo, Jingjing
影响因子：
9.6
作者：
Di Giantomasso, D;May, CN;Bellomo, R
通讯作者：
Bellomo, R
影响因子：
5.6
作者：
Fan, Feng;Lei, Meng
通讯作者：
Lei, Meng
DOI：
10.1164/rccm.201706-1255oc
发表时间：
2018-07-01
影响因子：
24.7
作者：
Gaudry, Stephane;Hajage, David;Dreyfuss, Didier
通讯作者：
Dreyfuss, Didier