Mechanisms Underlying Curcumin-Induced Neuroprotection in Cerebral Ischemia.
Mechanisms Underlying Curcumin-Induced Neuroprotection in Cerebral Ischemia.
复制标题
姜黄素诱导脑缺血神经保护作用的机制。
DOI：
10.3389/fphar.2022.893118
复制
发表时间：
2022
影响因子：
5.6
通讯作者：
Lei, Meng
中科院分区：
文献类型：
--
作者：
Fan, Feng;Lei, Meng
关键词：
缺血性中风是全世界死亡和残疾的主要原因，恢复缺血脑组织的血流是目前主要的治疗策略。然而，脑缺血后的再灌注会导致活性氧产生过多、炎症细胞募集、炎症介质释放、细胞死亡、线粒体功能障碍、内质网应激和血脑屏障损伤；这些病理机制会进一步加重脑组织损伤，最终影响神经功能的恢复。开发对脑缺血个体具有多靶点干预作用的药物引起了研究人员的关注。大量研究证实姜黄素通过多种机制在脑缺血中发挥重要的神经保护作用，包括抗氧化、抗炎、抗凋亡、保护血脑屏障、恢复线粒体功能和结构、恢复脑循环、减少梗死体积、改善脑水肿、促进血脑屏障修复、改善神经功能等。因此，总结最新文献结果，明确姜黄素治疗脑缺血的潜在作用机制，将为今后姜黄素的临床应用提供依据和指导。
Ischemic stroke is the leading cause of death and disability worldwide, and restoring the blood flow to ischemic brain tissues is currently the main therapeutic strategy. However, reperfusion after brain ischemia leads to excessive reactive oxygen species production, inflammatory cell recruitment, the release of inflammatory mediators, cell death, mitochondrial dysfunction, endoplasmic reticulum stress, and blood–brain barrier damage; these pathological mechanisms will further aggravate brain tissue injury, ultimately affecting the recovery of neurological functions. It has attracted the attention of researchers to develop drugs with multitarget intervention effects for individuals with cerebral ischemia. A large number of studies have established that curcumin plays a significant neuroprotective role in cerebral ischemia via various mechanisms, including antioxidation, anti-inflammation, anti-apoptosis, protection of the blood–brain barrier, and restoration of mitochondrial function and structure, restoring cerebral circulation, reducing infarct volume, improving brain edema, promoting blood–brain barrier repair, and improving the neurological functions. Therefore, summarizing the results from the latest literature and identifying the potential mechanisms of action of curcumin in cerebral ischemia will serve as a basis and guidance for the clinical applications of curcumin in the future.
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DOI：
10.1016/j.biocel.2008.06.010
发表时间：
2009-01
影响因子：
4
作者：
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