Glycyrrhizic acid ameliorates submandibular gland oxidative stress, autophagy and vascular dysfunction in rat model of type 1 diabetes.
Glycyrrhizic acid ameliorates submandibular gland oxidative stress, autophagy and vascular dysfunction in rat model of type 1 diabetes.
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DOI：
10.1038/s41598-021-04594-w
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发表时间：
2022-01-14
影响因子：
4.6
通讯作者：
Elsherbini AM
中科院分区：
文献类型：
--
作者：
Asseri SM;Elsherbiny NM;El-Sherbiny M;Sherif IO;Alsamman AM;Maysarah NM;Elsherbini AM
糖尿病（DM）和相关并发症的负担在全球范围内不断增加，影响许多器官功能，包括下颌下腺（SMG）。本研究旨在探讨甘草酸（GA）对糖尿病所致SMG损伤的潜在改善作用。在I型糖尿病大鼠模型上进行GA治疗的实验评估。将动物分配到三个组：对照组、糖尿病组和GA治疗的糖尿病组。8周后，处理SMG以评估氧化应激标志物、自噬相关蛋白; LC 3、Beclin-1和P62、血管调节因子ET-1、水通道蛋白（AQP 1.4和5）、SIRT 1蛋白表达以及LC 3和AQP 5 mRNA表达。此外，SMG的实质结构进行了检查。GA通过调节SIRT 1、AQP及相应的LC-3、P62和Beclin-1水平，使SMG氧化应激指标和ET-1水平接近正常水平，从而减轻糖尿病引起的SMG损伤。GA可能通过调节氧化应激、自噬和血管生成来治疗糖尿病诱导的SMG损伤。
The burden of diabetes mellitus (DM) and associated complications is increasing worldwide, affecting many organ functionalities including submandibular glands (SMG). The present study aims to investigate the potential ameliorative effect of glycyrrhizic acid (GA) on diabetes-induced SMG damage. Experimental evaluation of GA treatment was conducted on a rat model of type I diabetes. Animals were assigned to three groups; control, diabetic and GA treated diabetic groups. After 8 weeks, the SMG was processed for assessment of oxidative stress markers, autophagy related proteins; LC3, Beclin-1 and P62, vascular regulator ET-1, aquaporins (AQPs 1.4 and 5), SIRT1 protein expressions in addition to LC3 and AQP5 mRNA expressions. Also, parenchymal structures of the SMG were examined. GA alleviated the diabetes-induced SMG damage via restoring the SMG levels of oxidative stress markers and ET-1 almost near to the normal levels most probably via regulation of SIRT1, AQPs and accordingly LC-3, P62 and Beclin-1levels. GA could be a promising candidate for the treatment of diabetes-induced SMG damage via regulating oxidative stress, autophagy and angiogenesis.
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