Changes in aortic pulse wave velocity of four thoracic aortic stent grafts in an ex vivo porcine model.
Changes in aortic pulse wave velocity of four thoracic aortic stent grafts in an ex vivo porcine model.
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DOI：
10.1371/journal.pone.0186080
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Trimarchi S
中科院分区：
文献类型：
--
作者：
de Beaufort HWL;Coda M;Conti M;van Bakel TMJ;Nauta FJH;Lanzarone E;Moll FL;van Herwaarden JA;Auricchio F;Trimarchi S
胸主动脉腔内修复术（TEVAR）已被证明会导致主动脉僵硬度增加。本研究的目的是在对照实验环境中研究覆膜支架类型和覆膜支架长度对主动脉僵硬度的影响。将20个猪胸主动脉连接到脉动模拟环系统。在两个部位记录腔内压力，以测量每根主动脉的脉搏波速度（PWV）：覆膜支架展开前（t1）; 100 mm长覆膜支架展开后（t2）;通过第二个100 mm长覆膜支架展开远端延伸后（t3）。评价了四种不同类型的覆膜支架（Conformable戈尔® TAG®器械、博尔顿Relay®器械、Cook Zenith Alpha™和Medtronic Valiant®）。对于20例动脉瘤的总队列，在展开100 mm近端覆膜支架后，PWV平均增加0.6 m/s或基线PWV的8.9%（P<0.001），在覆膜支架远端延伸后，PWV平均增加1.4 m/s或基线PWV的23.0%（P<0.001）。单变量回归分析显示主动脉PWV与覆膜支架覆盖范围之间存在显著相关性（P<0.001），但基线主动脉长度、基线主动脉PWV或覆膜支架类型对t2或t3时PWV的百分比增加无显著影响。在该实验装置中，在使用四种类型的覆膜支架展开后，主动脉硬度显著增加，主动脉硬度的增加取决于覆膜支架的覆盖程度。
Thoracic endovascular aortic repair (TEVAR) has been shown to lead to increased aortic stiffness. The aim of this study was to investigate the effect of stent graft type and stent graft length on aortic stiffness in a controlled, experimental setting. Twenty porcine thoracic aortas were connected to a pulsatile mock loop system. Intraluminal pressure was recorded at two sites in order to measure pulse wave velocity (PWV) for each aorta: before stent graft deployment (t1); after deployment of a 100-mm long stent graft (t2); and after distal extension through deployment of a second 100-mm long stent graft (t3). Four different types of stent grafts (Conformable Gore® TAG® Device, Bolton Relay® Device, Cook Zenith Alpha™, and Medtronic Valiant®) were evaluated. For the total cohort of 20 aortas, PWV increased by a mean 0.6 m/s or 8.9% of baseline PWV after deployment of a 100-mm proximal stent graft (P<0.001), and by a mean 1.4 m/s or 23.0% of baseline PWV after distal extension of the stent graft (P<0.001). Univariable regression analysis showed a significant correlation between aortic PWV and extent of stent graft coverage, (P<0.001), but no significant effect of baseline aortic length, baseline aortic PWV, or stent graft type on the percentual increase in PWV at t2 or at t3. In this experimental set-up, aortic stiffness increased significantly after stent graft deployment with each of the four types of stent graft, with the increase in aortic stiffness depending on the extent of stent graft coverage.
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影响因子：
39.3
作者：
Erbel, Raimund;Aboyans, Victor;Vrints, Christiaan J. M.
通讯作者：
Vrints, Christiaan J. M.
影响因子：
3.9
作者：
Li, Wen-Chun;Yu, Ming-Hua;Zeng, Yan-Jun
通讯作者：
Zeng, Yan-Jun
DOI：
10.1161/hyp.0000000000000033
发表时间：
2015-09
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Townsend RR;Wilkinson IB;Schiffrin EL;Avolio AP;Chirinos JA;Cockcroft JR;Heffernan KS;Lakatta EG;McEniery CM;Mitchell GF;Najjar SS;Nichols WW;Urbina EM;Weber T;American Heart Association Council on Hypertension
通讯作者：
American Heart Association Council on Hypertension
影响因子：
2.4
作者：
Deplano, Valerie;Boufi, Mourad;Bertrand, Eric
通讯作者：
Bertrand, Eric
影响因子：
1.5
作者：
Tzilalis, Vasileios D.;Kamvysis, Dimitrios;Boudoulas, Harisios
通讯作者：
Boudoulas, Harisios