Viral nanoparticles decorated with novel EGFL7 ligands enable intravital imaging of tumor neovasculature.
Viral nanoparticles decorated with novel EGFL7 ligands enable intravital imaging of tumor neovasculature.
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DOI：
10.1039/c7nr02558k
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发表时间：
2017-08-24
期刊：
影响因子：
6.7
通讯作者：
Lewis JD
中科院分区：
文献类型：
--
作者：
Cho CF;Yu L;Nsiama TK;Kadam AN;Raturi A;Shukla S;Amadei GA;Steinmetz NF;Luyt LG;Lewis JD
Angiogenesis is a dynamic process fundamental to the development of solid tumors. Epidermal growth factor-like domain 7 (EGFL7) is a protein whose expression is restricted to endothelial cells undergoing active remodeling that has emerged as a key mediator of this process. EGFL7 expression is associated with poor outcome in several cancers, making it a promising target for imaging or therapeutic strategies. Here, EGFL7 is explored as a molecular target for active neovascularization. Using a combinatorial peptide screening approach, we describe the discovery and characterization of a novel high affinity EGFL7-binding peptide, E7p72, that specifically targets human endothelial cells. Viral nanoparticles decorated with E7p72 peptides specifically target tumor-associated neovasculature with high specificity as assessed by intravital imaging. This work highlights the value of EGFL7 as a target for angiogenic vessels and opens the door for novel targeted therapeutic approaches.
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DOI：
10.1007/978-1-62703-751-8_16
发表时间：
2014-01-01
期刊：
VIRUS HYBRIDS AS NANOMATERIALS: METHODS AND PROTOCOLS
影响因子：
--
作者：
Cho, Choi-Fong;Shukla, Sourabh;Lewis, John D.
通讯作者：
Lewis, John D.
影响因子：
15.9
作者：
Johnson, Leisa;Huseni, Mahrukh;Hegde, Priti S.
通讯作者：
Hegde, Priti S.
影响因子：
2.5
作者：
Fitch, MJ;Campagnolo, L;Stuhlmann, H
通讯作者：
Stuhlmann, H
影响因子：
8
作者：
Arpaia, E.;Blaser, H.;Quintela-Fandino, M.;Duncan, G.;Leong, H. S.;Ablack, A.;Nambiar, S. C.;Lind, E. F.;Silvester, J.;Fleming, C. K.;Rufini, A.;Tusche, M. W.;Bruestle, A.;Ohashi, P. S.;Lewis, J. D.;Mak, T. W.
通讯作者：
Mak, T. W.
影响因子：
6.7
作者：
Koudelka KJ;Destito G;Plummer EM;Trauger SA;Siuzdak G;Manchester M
通讯作者：
Manchester M